In vitro cytotoxicity evaluation of diversely substituted N-aryl-2-oxindoles

被引：0
|
作者：
Atul Manvar
Abhay Bavishi
Rajesh Loriya
Manu Jaggi
Anamik Shah
机构：
[1] Saurashtra University,National Facility for Drug Discovery, Department of Chemistry
[2] University College Dublin,Centre for Synthesis & Chemical Biology, School of Chemistry & Chemical Biology
[3] Adventus Laboratories (India) Pvt. Ltd.,R & D Division
[4] Medicinal Chemistry Division,Lupin Research Park
[5] Fresenius Kabi (India) Pvt. Ltd.,R & D Division
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
2-Indolinones; In vitro; Anticancer; Cytotoxicity; MTT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In continuation with our previous work, structurally diverse 2-indolinones bearing 2,6-dichloroaryl fragment at N1 and (hetero)aryl benzylidene at C3 were evaluated for their antitumor activity on a panel of cancer cell lines such as MCF-7 (breast), MiapaCa2 (pancreas), KB (oral), HuTu80 (stomach), L132 (lung), B16F10 (melanoma), and Molt4 (leukemia) from various human organs. Among the screened compound library, molecules 4e,4k, and 4r have shown excellent cytotoxicity on a stomach cancer cell line. Moreover, a significant number of compounds have also shown promising cytotoxicity on pancreas and oral cancer cell lines.
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页码：3076 / 3084
页数：8
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