Recoding a cocaine-place memory engram to a neutral engram in the hippocampus

被引：0
|
作者：
Stéphanie Trouche
Pavel V Perestenko
Gido M van de Ven
Claire T Bratley
Colin G McNamara
Natalia Campo-Urriza
S Lucas Black
Leon G Reijmers
David Dupret
机构：
[1] Medical Research Council Brain Network Dynamics Unit,Department of Pharmacology
[2] University of Oxford,Department of Neuroscience
[3] School of Medicine,undefined
[4] Tufts University,undefined
来源：
Nature Neuroscience | 2016年 / 19卷
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摘要：
Subsets of hippocampal neurons store map-like representations of experienced environments. The authors optogenetically silenced a neuronal population active in an environment and saw an alternative map emerge. In a cocaine-paired environment, this approach neutralized drug-place preference, implicating recoding of spatial memory engrams as strategy for alleviating maladaptive behaviors.
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页码：564 / 567
页数：3
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