Effects of delta-sleep-inducing peptide in cerebral ischemia in rats

被引：4

作者：

Shandra A.A. ^{[1
]}

Godlevskii L.S. ^{[1
]}

Brusentsov A.I. ^{[1
]}

Vast'yanov R.S. ^{[1
]}

Karlyuga V.A. ^{[1
]}

Dzygal A.F. ^{[2
]}

Nikel B. ^{[1
]}

机构：

[1] Department of Normal Physiology, State Medical University, 270100 Odessa

[2] Asta Medica AG, 6000 Frankfurt 1

来源：

Neuroscience and Behavioral Physiology | 1998年 / 28卷 / 4期

关键词：

Delta-sleep-inducing peptide; Ischemia; MK-801; Neuroprotective effect; Stroke;

D O I：

10.1007/BF02464804

中图分类号：

学科分类号：

摘要：

Experimental studies were carried out to investigate the neuroprotective effects of delta-sleep-inducing peptide in animals with cerebral ischemia induced by bilateral compression of both carotid arteries, and to compare the efficacy of this peptide with that of MK-801. These studies led to the conclusion that the peptide had pronounced anti-ischemic effects, which were evident within 24 h and consisted of reductions in the severity of postural abnormalities in rats with bilateral cerebral ischemia, along with a reduction in lethality. Comparison of the efficacies of peptide and MK-801 showed the peptide to have the greater neuroprotective effect. These results are regarded as providing an experimental basis for using the peptide as a therapeutic agent in patients with stroke. ©1998 Plenum Publishing Corporation.

引用

页码：443 / 446

页数：3

共 14 条

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