Stochastic model of the formation of cancer metastases via cancer stem cells

被引：0
作者：
Vladimir P. Zhdanov
机构：
[1] Chalmers University of Technology,Department of Applied Physics
[2] Boreskov Institute of Catalysis,undefined
[3] Russian Academy of Sciences,undefined
来源：
European Biophysics Journal | 2008年 / 37卷
关键词：
Cancer; Metastases; Cancer stem and progenitor cells; Premetastatic niches; Proliferation, differentiation and death of cells; Mean-field kinetic equations; Monte Carlo simulations;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The author presents Monte Carlo simulations of the temporal kinetics of the formation of cancer metastases with emphasis on cancer stem cells. The model used implies the existence of premetastatic niches. The population of cancer stem cells located outside tumors and inducing the formation of new tumors in niches is considered to be heterogeneous. If the niches are equivalent with respect to the formation of metastases, the kinetics are predicted to exhibit an induction period and then rapid growth of the number of metastases. If the niches are heterogeneous, the kinetics are found to be more gradual.
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页码：1329 / 1334
页数：5
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