Somatic glypican 3 (GPC3) mutations in Wilms' tumour

被引:0
作者
G R M White
A M Kelsey
J M Varley
J M Birch
机构
[1] Cancer Research UK Cancer Genetics Group,Department of Histopathology
[2] Paterson Institute for Cancer Research,undefined
[3] Royal Manchester Children's Hospital,undefined
[4] Cancer Research UK Paediatric & Familial Cancer Research Group,undefined
[5] Royal Manchester Children's Hospital,undefined
来源
British Journal of Cancer | 2002年 / 86卷
关键词
Wilms' tumour; glypican 3; mutation;
D O I
暂无
中图分类号
学科分类号
摘要
Tumour and normal tissue from 41 male cases of Wilms' tumour were screened to determine the presence of sequence variants in the glypican 3 (GPC3) gene. Two non-conservative single base changes were present in tumour tissue only. These findings imply a possible role for GPC3 in Wilms' tumour development.
引用
收藏
页码:1920 / 1922
页数:2
相关论文
共 85 条
[1]  
Blair V(1994)Patterns and temporal trends in the incidence of malignant disease in children: II solid tumours of childhood Eur J Cancer 30A 1498-1511
[2]  
Birch JM(1993)PCR buffer optimization with uniform temperature regimen to facilitate automation PCR Methods and Applications 2 234-240
[3]  
Blanchard MM(1998)Risk of cancer during the first four years of life in children from the Beckwith-Wiedemann Syndrome registry J Pediatr 132 398-400
[4]  
Taillon-Miller P(2001)Developmental roles of the glypicans Semin Cell Dev Biol 12 117-125
[5]  
Nowotny P(1998)OCI-5/GPC3, a glypican encoded by a gene that is mutated in the Simpson-Golabi-Behmel overgrowth syndrome, induces apoptosis in a cell line-specific manner J Cell Biol 141 1407-1414
[6]  
Nowotny V(1994)The genetics of Wilms' tumor – a case of disrupted development Annu Rev Genet 28 523-558
[7]  
DeBaun MR(1997)Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5′-promoter and 3′-terminal ends of the human glypican 3 (GPC3) gene Genomics 45 48-58
[8]  
Tucker MA(1998)Wilms' Tumor Genetics Am J Med Genet 79 260-267
[9]  
De Cat B(1996)Simpson-Golabi-Behmel Syndrome: genotype/phenotype analysis of 18 Affected males from 7 unrelated families Am J Med Genet 66 227-234
[10]  
David G(1997)Large scale deletions in the J Med Genet 34 480-483