Synthesis and biological activity of the 2-amino-4-(4-iodophenyl)amino-6-methylpyrimidine isosteric analogs

被引：0

作者：

A. V. Erkin

V. I. Krutikov

机构：

[1] St. Petersburg State Institute of Technology (Technical University),

来源：

Russian Journal of General Chemistry | 2013年 / 83卷

关键词：

Halogen Atom; Hydrogen Chloride; Mycobacterium Smegmatis; Phosphorus Oxychloride; Aqueous Potassium Hydroxide;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Transformation of the structure of 6-methylisocytosine results in the isosteric analogs of 2-amino-4-(4-iodophenyl)amino-6-methylpyrimidine exhibiting tuberculocidal properties. The level of biological activity of the synthesized compounds depends on the site of location of the halogen atom.

引用

页码：538 / 541

页数：3

共 9 条

[1] Synthesis and biological activity of the 2-amino-4-(4-iodophenyl)amino-6-methylpyrimidine isosteric analogs
Erkin, A. V.
Krutikov, V. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2013, 83 (03) : 538 - 541
[2] Effect of the structural modification of 2-benzylamino-4-(4-iodophenyl)amino-6-methylpyrimidine on the biological activity of its derivatives
A. V. Erkin
V. I. Krutikov
Russian Journal of General Chemistry, 2012, 82 : 1567 - 1572
[3] Effect of the structural modification of 2-benzylamino-4-(4-iodophenyl)amino-6-methylpyrimidine on the biological activity of its derivatives
Erkin, A. V.
Krutikov, V. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2012, 82 (09) : 1567 - 1572
[4] Effect of Halogen Atom Localization on the Level of Antimycobacterial Activity of 2-Amino-4-arylamino-6-methylpyrimidines
Erkin, A. V.
Krutikov, V. I.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2010, 80 (04) : 818 - 824
[5] Effect of halogen atom localization on the level of antimycobacterial activity of 2-amino-4-arylamino-6-methylpyrimidines
A. V. Erkin
V. I. Krutikov
Russian Journal of General Chemistry, 2010, 80 : 818 - 824
[6] Synthesis and Antimicobacterial Activity of 2-Substituted 4-Arylamino-6-methylpyrimidines
Erkin, A. V.
Krutikov, V. I.
Smirnova, E. B.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2008, 78 (10) : 1944 - 1948
[7] Synthesis and antimicobacterial activity of 2-substituted 4-arylamino-6-methylpyrimidines
A. V. Erkin
V. I. Krutikov
E. B. Smirnova
Russian Journal of General Chemistry, 2008, 78 : 1944 - 1948
[8] An efficient and convenient protocol for the synthesis of optically active [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives containing L-amino acid moieties
Foroughifar, Naesr
Ebrahimi, Sattar
Mobinikhaledi, Akbar
Mozafari, Reza
HETEROCYCLIC COMMUNICATIONS, 2011, 17 (5-6) : 211 - 214
[9] An Efficient and Convenient Protocol for the Synthesis of Optically Active 1,2,4-Triazolo-[3,4-b]-[1,3,4]-Thiadiazole, 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives having L-Amino Acid Moieties
Foroughifar, Naser
Ebrahimi, Sattar
Mobinikhaldei, Akbar
Mozafari, Reza
SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE, 2012, 65 : 1 - 4

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