A Case of Glomangiopericytoma at the Nasal Septum

被引：11

作者：

Anzai T. ^{[1
]}

Saito T. ^{[2
]}

Tsuyama S. ^{[2
]}

Toh M. ^{[1
]}

Ikeda K. ^{[1
]}

Ito S. ^{[1
]}

机构：

[1] Department of Otorhinolaryngology Head and Neck Surgery, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo

[2] Department of Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo

来源：

Head and Neck Pathology | 2018年 / 12卷 / 4期

基金：

日本学术振兴会;

关键词：

Endoscopic sinus surgery; Glomangiopericytoma; Hemangiopericytoma; Nasal septum; β-Catenin;

D O I：

10.1007/s12105-017-0870-6

中图分类号：

学科分类号：

摘要：

Glomangiopericytoma (GPC) is a rare sinonasal perivascular tumor that accounts for < 0.5–1% of all sinonasal tumors. GPC is categorized as a low-grade neoplasm with borderline malignancy and a tendency of local recurrence. GPC is a rare mesenchymal neoplasm characterized by the perivascular proliferation of tumor cells, and it requires being distinguished from solitary fibrous tumors. Here, we report a case of GPC in a 68-year-old male patient who presented at the emergency room of our hospital with a complaint of sudden epistaxis. A small, reddish, protruding tumor was observed on the right nasal septum. A biopsy revealed a possible perivascular tumor such as a GPC or solitary fibrous tumor. Thus, we performed complete resection with endoscopic surgery. The size of the resected tumor was 12 × 5 mm, and it showed a uniform proliferation of oval-to-short spindle-shaped cells with slightly branching vascular structures. The tumor cells showed minimal cytologic atypia and there were an average of 3 mitoses in 10 high power fields. Necrosis was not observed. The tumor cells showed strong and diffuse nuclear immunostaining with beta catenin and were negative with STAT6, CD34 and bcl-2. The MIB-1 labeling index was approximately 5%. Genetic testing revealed CTNNB1 mutation (p.S33C). Thus, a diagnosis of low grade GPC was made on the biopsy and the patient could be successfully treated with endoscopic resection. © 2017, The Author(s).

引用

页码：572 / 575

页数：3

共 5 条

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