Synthesis and Properties of N-Alkyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-1H-pyrimidine-2,4-diones and Their 2-Thioanalogs

被引：0
|
作者：
K. A. Krasnov
V. G. Kartsev
M. N. Yurova
机构：
[1] St. Petersburg Mechnikov State Medical Academy,
[2] ZAO “INTERBIOSKRIN”,undefined
[3] Chernogolovka,undefined
[4] Moscow oblast,undefined
来源：
Russian Journal of Organic Chemistry | 2003年 / 39卷
关键词：
Spectroscopy; Ethyl; Organic Chemistry; Adduct; Alkaloid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Addition of N-substituted barbituric and 2-thiobarbituric acids to 3,4-dihydro-β-carboline results in formation of N-alkyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-1H-pyrimidine-2,4-diones and their 2-thioanalogs, which are structural analogs of alkaloids from annomontin group. Acylation of 1,3-dimethyl-substituted adduct is accompanied by opening of the tetrahydropyridine ring furnishing N-{2-[2-(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidin-5-ylidenomethyl)-1H-indol-3-yl]ethyl}acetamide. The structure of compounds synthesized was studied by means of 1H NMR spectroscopy.
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页码：596 / 600
页数：4
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