Synthesis and Properties of N-Alkyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-1H-pyrimidine-2,4-diones and Their 2-Thioanalogs

被引：0

作者：

K. A. Krasnov

V. G. Kartsev

M. N. Yurova

机构：

[1] St. Petersburg Mechnikov State Medical Academy,

[2] ZAO “INTERBIOSKRIN”,undefined

[3] Chernogolovka,undefined

[4] Moscow oblast,undefined

来源：

Russian Journal of Organic Chemistry | 2003年 / 39卷

关键词：

Spectroscopy; Ethyl; Organic Chemistry; Adduct; Alkaloid;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Addition of N-substituted barbituric and 2-thiobarbituric acids to 3,4-dihydro-β-carboline results in formation of N-alkyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-1H-pyrimidine-2,4-diones and their 2-thioanalogs, which are structural analogs of alkaloids from annomontin group. Acylation of 1,3-dimethyl-substituted adduct is accompanied by opening of the tetrahydropyridine ring furnishing N-{2-[2-(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidin-5-ylidenomethyl)-1H-indol-3-yl]ethyl}acetamide. The structure of compounds synthesized was studied by means of 1H NMR spectroscopy.

引用

页码：596 / 600

页数：4

共 33 条

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