Low birth weight, but not postnatal weight gain, aggravates the course of nephrotic syndrome

被引:0
作者
Christian Plank
Iris Östreicher
Katalin Dittrich
Rüdiger Waldherr
Manfred Voigt
Kerstin Amann
Wolfgang Rascher
Jörg Dötsch
机构
[1] University of Erlangen-Nuremberg,Department of Paediatrics, Kinder
[2] Institute for Clinical Pathology, and Jugendklinik
[3] Ernst-Moritz-Arndt-University of Greifswald,Department of Paediatrics
[4] University of Erlangen-Nuremberg,Department of Pathology
来源
Pediatric Nephrology | 2007年 / 22卷
关键词
Nephrotic syndrome; Child; Low birth weight; Small for gestational age; Intrauterine growth restriction;
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摘要
Clinical and animal studies have shown a higher risk of an aggravated course of renal disease in childhood after birth for babies small for gestational age (SGA). In addition relative “supernutrition” and fast weight gain in early infancy seem to support the development of later disease. In a retrospective analysis of 62 cases of idiopathic nephrotic syndrome treated between 1994 and 2004 at a university centre for paediatric nephrology, we related the course of disease to birth weight and to the weight gain in the first 2 years of life. Six children were born SGA (birth weight <−1.5 standard deviation score), and 56 were born as appropriate for gestational age (AGA). In all SGA children renal biopsy was performed, while only 55% of the AGA children underwent renal biopsy (P = 0.07), showing no difference in renal histology. In the SGA group, four of six patients developed steroid resistance (vs 12/56 AGA, P < 0.05). Of the SGA children, 83% needed antihypertensive treatment in the course of the disease compared to 39% of the AGA children (P = 0.07). The extent of weight gain between birth and 24 months of age did not influence the course of disease. In conclusion, we were able to find evidence for an aggravated course of idiopathic nephrotic syndrome in former SGA children. Independently of birth weight, weight gain in the first 2 years of life did not influence the course of disease.
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页码:1881 / 1889
页数:8
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