Overexpression of p53 tumor suppressor gene in pterygia

被引：0
作者：
O Weinstein
G Rosenthal
H Zirkin
T Monos
T Lifshitz
S Argov
机构：
[1] Soroka Medical Center Ben-Gurion University of the Negev Beer-Sheeva,Department of Ophthalmology
[2] Institute of Pathology Soroka Medical Center Ben-Gurion University of the Negev Beer-Sheva,undefined
来源：
Eye | 2002年 / 16卷
关键词：
pterygium; p53; neoplasia; degeneration; immunohistochemical staining;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose To assess p53 gene expression in pterygia with and without recurrence. The pathogenesis of pterygium has not yet been determined. The most widely recognized etiologic factor is ultraviolet radiation, which leads to degeneration of the conjunctiva. However, pterygium was recently found to have several tumor-like characteristics. The p53 gene is a common marker for neoplasia, and is known to control cell cycle, cell differentiation and apoptosis. In this study we examined the expression of the p53 gene in primary pterygia with and without recurrence, searching for the pathogenesis of this very common lesion and for a prognostic factor for recurrence.
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页码：619 / 621
页数：2
相关论文
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