Overexpression of p53 tumor suppressor gene in pterygia

被引：0
作者：
O Weinstein
G Rosenthal
H Zirkin
T Monos
T Lifshitz
S Argov
机构：
[1] Soroka Medical Center Ben-Gurion University of the Negev Beer-Sheeva,Department of Ophthalmology
[2] Institute of Pathology Soroka Medical Center Ben-Gurion University of the Negev Beer-Sheva,undefined
来源：
Eye | 2002年 / 16卷
关键词：
pterygium; p53; neoplasia; degeneration; immunohistochemical staining;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose To assess p53 gene expression in pterygia with and without recurrence. The pathogenesis of pterygium has not yet been determined. The most widely recognized etiologic factor is ultraviolet radiation, which leads to degeneration of the conjunctiva. However, pterygium was recently found to have several tumor-like characteristics. The p53 gene is a common marker for neoplasia, and is known to control cell cycle, cell differentiation and apoptosis. In this study we examined the expression of the p53 gene in primary pterygia with and without recurrence, searching for the pathogenesis of this very common lesion and for a prognostic factor for recurrence.
引用
收藏
页码：619 / 621
页数：2
相关论文
共 43 条
  • [1] Mackenzie FD(1992)Risk analysis in the development of pterygia Ophthalmology 99 1056-1061
  • [2] Hirsh LW(1999)Use of mitimycin C with conjunctival autograft in pterygium surgery in Asian-Canadians Opthalmology 106 1512-1515
  • [3] Battistutta D(1998)Meta-analysis on the recurrence rates after bare sclera resection with and without mitimycin C use and conjunctival autograft placement in surgery for primary pterygium Br J Ophthalmol 82 661-665
  • [4] Green A(1994)Mutation in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis Cancer Res 54 4855-4878
  • [5] Wong VA(1993)Clinical implications of the p53 tumor-suppressor gene New England J Med 28 1318-1328
  • [6] Law FCH(1995)P53 accumulation in benign breast biopsy specimens Hum Pathol 26 155-158
  • [7] Sanchez-Thorin JC(1997)Microsatellite instability and loss of heterozygosity in human pterygia Br J Ophthalmol 81 493-496
  • [8] Rocha G(1997)Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium Am J Ophthalmol 123 404-405
  • [9] Yelin JB(1997)P53 expression in altered limbal basal cells of pigueculae, pterygia, and limbal tumors Curr Eye Res 16 1179-1192
  • [10] Greenblatt MS(1998)Expression of p53 protein in pterygia Eur J Ophthalmol 8 157-161
12345