Clinical and dosimetric evaluation of RapidArc versus standard sliding window IMRT in the treatment of head and neck cancer; [Klinische und dosimetrische Auswertung von RapidArc versus dynamischer („sliding-window“) IMRT bei der Behandlung von Kopf-Hals-Tumoren]

被引：0
作者：
Smet S. [1 ]
Lambrecht M. [1 ]
Vanstraelen B. [1 ]
Nuyts S. [1 ]
机构：
[1] Department of Radiation Oncology, University Hospitals Leuven, Herestraat 49, Leuven
来源：
Strahlentherapie und Onkologie | 2015年 / 191卷 / 1期
关键词：
Head and neck neoplasms; Intensity-modulated radiotherapy; Organs at risk; Toxicity; Treatment outcome;
D O I：
10.1007/s00066-014-0742-x
中图分类号：
学科分类号：
摘要：
Background: Several planning studies have already proven the substantial dosimetric advantages of RapidArc (RA) over standard intensity-modulated radiotherapy. We retrospectively compared RapidArc and standard sliding window IMRT (swIMRT) in locally advanced head and neck cancer, looking both at dosimetrics as well as toxicity and outcome.; Methods: CT datasets of 78 patients treated with swIMRT and 79 patients treated with RA were included. To compare the resulting dose distributions, the dose–volume parameters were evaluated for the planning target volumes (PTVs), clinical target volumes (CTVs), and organs at risk (OARs), and the number of MU were calculated. Acute toxicity was assessed by the Common Toxicity Criteria version 3.0.; Results: PTV coverage with the 95 % isodose was slightly better for RA. Dose distribution has proven to be significantly more homogenous with RA and led to a reduction of 62 % in MU with better OAR sparing. As for toxicity, more grade 3 mucositis and dysphagia was observed for swIMRT, though we observed more grade 3 dermatitis for RA.; Conclusion: In our retrospective analysis, RA had better target coverage and better sparing of the OAR. Overall, the grade of acute toxicity was lower for RA than for swIMRT for the same types of tumor locations, except for the grade of dermatitis. © 2014, Springer-Verlag Berlin Heidelberg.
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页码：43 / 50
页数：7
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