Adaptive designs for dual-agent phase I dose-escalation studies

被引：0
|
作者：
Jennifer A. Harrington
Graham M. Wheeler
Michael J. Sweeting
Adrian P. Mander
Duncan I. Jodrell
机构：
[1] University of Cambridge,Department of Oncology
[2] Cancer Research UK Cambridge Institute,undefined
[3] Li Ka Shing Centre,undefined
[4] MRC Biostatistics Unit Hub for Trials Methodology Research,undefined
[5] Institute of Public Health,undefined
来源：
Nature Reviews Clinical Oncology | 2013年 / 10卷
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摘要：
With increasing numbers of anticancer drugs requiring testing, new adaptive model-based phase I trial designs can improve on current practice by exploring a wider range of dose combinations than standard phase I methods. In this Review, the authors describe the methods available as well as the opportunities and challenges faced in dual-agent phase I trials.
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页码：277 / 288
页数：11
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