Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938II. Structure Elucidation

被引：0
作者：
Takashi Fukuda
Hiroshi Tomoda
Satoshi Ōmura
机构：
[1] School of Pharmaceutical Sciences,
[2] Kitasato University,undefined
[3] Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences,undefined
[4] Kitasato University,undefined
[5] The Kitasato Institute,undefined
来源：
The Journal of Antibiotics | 2005年 / 58卷
关键词：
citridones; phenylfuropyridone; anti-infective; azole potentiator;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The structures of citridones A, B, B′ and C, new potentiators of miconazole activity against Candida albicans produced by Penicillium sp. FKI-1938, were elucidated by various spectroscopic analyses including UV, NMR, and MS and degradation experiments. Although citridones B and B′ were isolated as a mixture, each structure was also elucidated, indicating that they exist in equilibrium of hemiacetal epimerization. Citridones A, B and B′ have a similar phenylfuropyridone moiety.
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页码：315 / 321
页数：6
相关论文
共 35 条
[1]  
Fukuda T(2005)Citridones, potentiators of antifungal miconazole activity, produced by J Antibiot 58 309-314
[2]  
Yamaguchi Y(2002) sp. FKI-1938 I. Taxonomy, fermentation, isolation, and biological properties J Antibiot 55 6-18
[3]  
Masuma R(1998)CJ-15,696 and its analogs, new furopyridine antibiotics from the fungus Acta Chem Scand 52 631-634
[4]  
Tomoda H(2004): fermentation, isolation, structural elucidation, biotransformation and antibacterial activities J Org Chem 69 1872-1879
[5]  
Ōmura S(1998)Cladobotryal: a fungal metabolite with a novel ring system Tetrahedron 54 9195-9206
[6]  
Sakemi S(undefined)Model studies and first synthesis of the antifungal and antibacterial agent cladobotryal undefined undefined undefined-undefined
[7]  
Border J(undefined)Synthesis and evaluation of a putative acyl tetramic acid intermediate in tenellin biosynthesis in undefined undefined undefined-undefined
[8]  
Decosta DL(undefined). A new role for tyrosine undefined undefined undefined-undefined
[9]  
Dekker KA(undefined)undefined undefined undefined undefined-undefined
[10]  
Hirai H(undefined)undefined undefined undefined undefined-undefined
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