Immunoexpression of Metallothionein in Oral Squamous Cell Carcinoma

被引：1

作者：

Dumpala R.K. ^{[1
]}

Guttikonda V.R. ^{[1
]}

机构：

[1] Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, 507002, Andhra Pradesh

来源：

Journal of Maxillofacial and Oral Surgery | 2015年 / 14卷 / 4期

关键词：

Immunohistochemistry; Metallothionein; Oral squamous cell carcinoma; Prognosis;

D O I：

10.1007/s12663-015-0773-6

中图分类号：

学科分类号：

摘要：

Background and Objectives: Metallothionein (MT) is a family of ubiquitous low molecular weight (7 kDa), intracellular (cytoplasmic/nuclear), cysteine rich proteins with high affinity for heavy metals, present in both normal cells and neoplastic cells. Increased expression of MT has been reported to be associated with poor prognosis in various tumours. The objectives of the present study were to compare the expression of MT in normal subjects and in patients with oral squamous cell carcinoma (OSCC), to correlate the expression of MT with respect to clinical staging of OSCC and to evaluate the expression of MT with respect to different histopathological grades of OSCC. Methods: Thirty cases of OSCC were staged clinically and graded histopathologically. Immunohistochemical method was used to detect the expression of MT in OSCC. The scores obtained were documented and compared statistically. Results: MT immunoreactivity was noticed in all cases of OSCC. A statistically significant difference was observed in immunoreactivity of MT between the normal and OSCC, and in different histopathological grades of OSCC (p = 0.00001*). However, no statistical significance was found in a number of immunopositive cells in different clinical stages of OSCC (p = 0.7573). Conclusion: The MT immunoexpression increased from low grade to high grade OSCC. Hence, increased expression of MT may be related to poor prognosis in patients with OSCC. © 2015, The Association of Oral and Maxillofacial Surgeons of India.

引用

页码：914 / 919

页数：5

共 19 条

[1]

Ribeiro A.L.R., Nobre R.M., Rocha G.C.M.A., Lobato H.I.S., Junior S.M.A., Jaeger R.G., Expression of metallothionein in ameloblastoma. A regulatory molecule, J Oral Pathol Med, 40, pp. 516-519, (2011)

[2]

Dziegel P., Expression of metallothioneins in tumour cells, Pol J Pathol, 55, 4, pp. 3-12, (2004)

[3]

Ebert M.P.A., Gunther T., Hoffmann J., Et al., Expression of metallothionein II in intestinal metaplasia, dysplasia and gastric cancer, Cancer Res, 60, pp. 1995-2001, (2000)

[4]

Raleigh J.A., Chou S.C., Calkins-Adams D.P., Ballenger C.A., Novotny D.B., Varia M.A., A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas, Clin Cancer Res, 6, pp. 855-862, (2000)

[5]

Szelachowska J., Dziegiel P., Jelen-Krzeszewska J., Jelen M., Tarkowski R., Spytkowska B., Et al., Correlation of metallothionein expression with clinical progression of cancer in the oral cavity, Anti Cancer Res, 29, pp. 589-596, (2009)

[6]

Szajerka A., Dziegiel P., Szajerka T., Zabel M., Windowski J., Grzebieniak Z., Immunohistochemical evaluation of metallothionein, mcm-2 and Ki-67 antigen expression in tumors of adrenal cortex, Anticancer Res, 28, pp. 2959-2966, (2008)

[7]

Struys T., Krage T., Martens W., Theunissen E., Moreels M., Lambrichts I., Metallothionein: a possible new marker for human dental pulp stem cells, Eur Cells Mater, 14, 2, (2007)

[8]

Pontes H.A.R., Xavier F.C.A., da Silva T.S.P., Fonseca F.P., Paiva H.B., Pontes F.S.C., Et al., Metallothionein and p-Akt proteins in oral dysplasia and in oral squamous cell carcinoma: an immunohistochemical study, J Oral Pathol Med, 38, pp. 644-650, (2009)

[9]

Muramatsu Y., Hasegawa Y., Fukano H., Ogawa T., Namuba M., Mouri K., Et al., Metallothionein immunoreactivity in head and neck carcinomas

[10]

special reference to clinical behaviours and chemotherapy responses, Anticancer Res, 20, 1A, pp. 257-264, (2000)

← 1 2 →