Voltammetric and spectrophotometric study on the complexation of glibenclamide with β-cyclodextrin

被引：0
作者：
Abd-Elgawad Radi
Shimaa Eissa
机构：
[1] Mansoura University,Department of Chemistry, Faculty of Science (Dumyat)
来源：
Journal of Inclusion Phenomena and Macrocyclic Chemistry | 2010年 / 68卷
关键词：
Cyclodextrin; Glibenclamide; Spectrophotometry; Voltammetry;
D O I：
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中图分类号：
学科分类号：
摘要：
The formation of an inclusion complex of glibenclamide (GL) with β-cyclodextrin (β-CD) in an aqueous ethanolic buffer solution of pH 7.0 has been investigated by UV spectrophotometry and differential pulse voltammetry and its stability constant is determined to be 855 and 354.15 M−1, respectively. The phase solubility profile, based on the spectrophotometric absorbance’s variations, was classified as AL-type, indicating the formation of 1:1 stoichiometric inclusion complex of glibenclamide with β-CD with a stability constant value, KS, of 846 M−1.
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页码：417 / 421
页数：4
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