Coexpression of natural killer cell antigens by T-cell large granular lymphocytes in hydroa vacciniforme lymphoproliferative disorder and the involvement of Vδ1 + epithelial-type γδT cells

被引:0
作者
Yoji Hirai
Keiji Iwatsuki
Takahide Takahashi
Tomoko Miyake
Yuki Nakagawa
Shogo Tanimoto
Yoshio Kawakami
Shin Morizane
机构
[1] Okayama University Graduate School of Medicine,Department of Dermatology
[2] Dentistry,Division of Dermatology
[3] and Pharmaceutical Sciences,Division of Medical Support
[4] Fukushima Rosai Hospital,undefined
[5] Okayama University Hospital,undefined
来源
International Journal of Hematology | 2023年 / 118卷
关键词
Hydroa vacciniforme; Chronic active EBV disease; Large granular lymphocyte; γδT-cell; NK-cell antigen;
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摘要
Hydroa vacciniforme lymphoproliferative disorder (HV-LPD) is a cutaneous variant of chronic active Epstein–Barr virus disease. We examined the coexpression of T- and natural killer (NK)-cell antigens in five patients with classic HV (cHV) and five with systemic HV (sHV). T-cell receptor (TCR) repertoire analysis was performed with high‑throughput sequencing. All five cHV patients had increased γδT cells (> 5%), whereas five sHV patients showed γδT- and αβT-cell dominance in two patients each, and a mixture of abnormal γδT and αβT cells in one. Circulating CD3 + T cells expressed CD16/CD56 at 7.8–42.3% and 1.1–9.7% in sHV and cHV, respectively. The percentage of CD16/CD56 + T cells was higher in the large granular lymphocyte or atypical T-cell fractions in sHV, but no TCR Vα24 invariant chain characteristic of NKT cells was detected. Considerable numbers of CD3 + cells expressing CD56 were observed in sHV skin infiltrates. Of the circulating γδT cells tested, TCR Vδ1 + cells characteristic of the epithelial type of γδT cells were dominant in two sHV cases. Thus, atypical αβT and γδT cells in HV-LPD can express NK-cell antigens, such as CD16 and CD56, and Vδ1 + epithelial-type γδT cells are a major cell type in some HV-LPD cases.
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页码:54 / 64
页数:10
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