The role of BMP4 signaling in trophoblast emergence from pluripotency

被引:0
作者
R. Michael Roberts
Toshihiko Ezashi
Jasmine Temple
Joseph R. Owen
Francesca Soncin
Mana M. Parast
机构
[1] University of Missouri,Division of Animal Sciences and Bond Life Sciences Center
[2] University of California San Diego,Department of Pathology
[3] Sanford Consortium for Regenerative Medicine,Department of Obstetrics, Gynecology, and Reproductive Sciences
[4] University of California San Diego,undefined
[5] Colorado Center for Reproductive Medicine,undefined
来源
Cellular and Molecular Life Sciences | 2022年 / 79卷
关键词
Bone Morphogenetic Protein; Trophectoderm; Inner cell mass; Epiblast; Cytotrophoblast; Trophoblast stem cells; Primed pluripotency; Naïve pluripotency;
D O I
暂无
中图分类号
学科分类号
摘要
The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has also been implicated in development of extraembryonic lineages, including trophectoderm (TE), in both mouse and human. In this review, we will provide an overview of this signaling pathway, with a focus on BMP4, and its role in emergence and development of TE in both early mouse and human embryogenesis. Subsequently, we will build on these in vivo data and discuss the utility of BMP4-based protocols for in vitro conversion of primed vs. naïve pluripotent stem cells (PSC) into trophoblast, and specifically into trophoblast stem cells (TSC). PSC-derived TSC could provide an abundant, reproducible, and ethically acceptable source of cells for modeling placental development.
引用
收藏
相关论文
共 50 条
  • [31] A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
    Alarmo, Emma-Leena
    Kuukasjarvi, Tuula
    Karhu, Ritva
    Kallioniemi, Anne
    BREAST CANCER RESEARCH AND TREATMENT, 2007, 103 (02) : 239 - 246
  • [32] Integrated RNA-seq and DNase-seq analyses identify phenotype-specific BMP4 signaling in breast cancer
    M. Ampuja
    T. Rantapero
    A. Rodriguez-Martinez
    M. Palmroth
    E. L. Alarmo
    M. Nykter
    A. Kallioniemi
    BMC Genomics, 18
  • [33] Pluripotency-independent induction of human trophoblast stem cells from fibroblasts
    Naama, Moriyah
    Rahamim, Moran
    Zayat, Valery
    Sebban, Shulamit
    Radwan, Ahmed
    Orzech, Dana
    Lasry, Rachel
    Ifrah, Annael
    Jaber, Mohammad
    Sabag, Ofra
    Yassen, Hazar
    Khatib, Areej
    Epsztejn-Litman, Silvina
    Novoselsky-Persky, Michal
    Makedonski, Kirill
    Deri, Noy
    Goldman-Wohl, Debra
    Cedar, Howard
    Yagel, Simcha
    Eiges, Rachel
    Buganim, Yosef
    NATURE COMMUNICATIONS, 2023, 14 (01)
  • [34] The impact of bone morphogenetic protein 4 (BMP4) on breast cancer metastasis in a mouse xenograft model
    Ampuja, M.
    Alarmo, E. L.
    Owens, P.
    Havunen, R.
    Gorska, A. E.
    Moses, H. L.
    Kallioniemi, A.
    CANCER LETTERS, 2016, 375 (02) : 238 - 244
  • [35] A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
    Emma-Leena Alarmo
    Tuula Kuukasjärvi
    Ritva Karhu
    Anne Kallioniemi
    Breast Cancer Research and Treatment, 2007, 103 : 239 - 246
  • [36] Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Selever, J
    Liu, W
    Lu, MF
    Behringer, RR
    Martin, JF
    DEVELOPMENTAL BIOLOGY, 2004, 276 (02) : 268 - 279
  • [37] BMP4 Protects Rat Pulmonary Arterial Smooth Muscle Cells from Apoptosis by PI3K/AKT/Smad1/5/8 Signaling
    Wu, Jian
    Yu, Zhigang
    Su, Dechun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (08) : 13738 - 13754
  • [38] Role of soluble endoglin in BMP9 signaling
    Lawera, Aleksandra
    Tong, Zhen
    Thorikay, Midory
    Redgrave, Rachael E.
    Cai, Jie
    van Dinther, Maarten
    Morrell, Nicholas W.
    Afink, Gijs B.
    Charnock-Jones, D. Stephen
    Arthur, Helen M.
    ten Dijke, Peter
    Li, Wei
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (36) : 17800 - 17808
  • [39] Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis
    Goldman, Devorah C.
    Donley, Nathan
    Christian, Jan L.
    MECHANISMS OF DEVELOPMENT, 2009, 126 (3-4) : 117 - 127
  • [40] Association between BMP4 gene polymorphism and in vitro embryo production traits in Gyr cows
    Ortiz, Wilder H.
    Quirino, Celia R.
    Silva, Amanda
    Oliveira, Clara S.
    Serapiao, Raquel V.
    Pacheco, Aline
    Bartholazzi, Aylton
    REVISTA COLOMBIANA DE CIENCIAS PECUARIAS, 2015, 28 (02) : 156 - 164