Efficacy and safety of intragastric balloon in the treatment of obesity in adolescent females

被引：0
作者：
Pezzo C.T. [1 ]
de Souza T.F. [1 ,2 ]
Fenero V. [1 ,3 ]
Suano-Souza F.I. [1 ,4 ]
Grecco E. [1 ,5 ]
Sarni R.O.S. [1 ]
机构：
[1] Department of Pediatrics, Faculdade de Medicina do ABC, Avenida Príncipe de Gales, 821, Santo André, CEP: 09060-600, São Paulo
[2] Hospital Estadual Mario Covas, Santo André
[3] Obesity Clinic, Faculdade de Medicine of ABC, Santo André
[4] Department of Pediatrics, Universidade Federal de São Paulo, São Paulo
[5] Faculdade de Medicina do ABC, Santo André
来源：
Nutrire | / 42卷 / 1期
关键词：
Adolescent; Child; Intragastric balloon; Obesity;
D O I：
10.1186/s41110-017-0052-z
中图分类号：
学科分类号：
摘要：
Background: The aims of this study are to evaluate the efficacy and safety of intragastric balloon (IB) to reduce the weight and body mass index (BMI) in severely obese adolescent females and to describe the changes in the liver enzymes and lipid and glucose metabolism biomarkers. Methods: This study included 10 severely obese post-menarche adolescent females. We evaluated anthropometric data, lipid profile, glucose metabolism biomarkers, and liver enzymes before insertion and after removal of the IB. Results: BMI and weight reduction were larger during the first month of intervention. Especially in the first week, there was a reduction of 1.74 ± 0.46 kg/m2 (p = 0.004) and 6.46 ± 1.52 kg (p = 0,002), respectively. After 3 months, there was an average BMI reduction of 4.29 ± 1.04 kg/m (p = 0.005) and weight reduction of 12.9 ± 3.08 kg (p = 0.004). From the initial moment to study conclusion, there was a statistically significant reduction in insulin levels (9.0 ± 2.8 U/mL; p = 0.012) and in homeostatic model assessment-insulin resistance (2.0 ± 0.6; p = 0.009). Five patients reported, during the first week, epigastric pain; nausea and vomiting were observed in two patients. No adolescents presented dysphagia during IB use. Conclusion: IB use in adolescent females with severe obesity in association with a conservative multidisciplinary treatment had a positive impact in BMI reduction, with few adverse effects. There was also an improvement in insulin resistance. © 2017, The Author(s).
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共 28 条
[1]  
Brown C.L., Halvorson E.E., Cohen G.M., Lazorick S., Skelton J.A., Addressing childhood obesity: opportunities for prevention, Pediatr Clin N Am, 62, pp. 1241-1261, (2015)
[2]  
Pesquisa de Orçamentos Familiares 2008-2009. Antropometria e Estado Nutricional de Crianças, Adolescentes e Adultos no Brasil, (2010)
[3]  
Kuschnir M.C., Bloch K.V., Szklo M., Klein C.H., Barufaldi L.A., Abreu Gde A., Schaan B., da Veiga G.V., da Silva T.L., de Vasconcellos M.T., Et al., ERICA: Prevalence of metabolic syndrome in Brazilian adolescents, Rev Saude Publica, 50, (2016)
[4]  
Williams C.L., Hayman L.L., Daniels S.R., Robinson T.N., Steinberger J., Paridon S., Bazzarre T., Cardiovascular health in childhood: a statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the young, American Heart Association, Circulation, 106, pp. 143-160, (2002)
[5]  
Inge T.H., Courcoulas A.P., Jenkins T.M., Michalsky M.P., Helmrath M.A., Brandt M.L., Harmon C.M., Zeller M.H., Chen M.K., Xanthakos S.A., Horlick M., Buncher C.R., Weight loss and health status 3 years after bariatric surgery in adolescents, N Engl J Med, 374, pp. 113-123, (2016)
[6]  
Abu Dayyeh B.K., Kumar N., Edmundowicz S.A., Jonnalagadda S., Larsen M., Sullivan S., Thompson C.C., Banerjee S., ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies, Gastrointest Endosc, 82, pp. 425-438, (2015)
[7]  
Kumar N., Endoscopic therapy for weight loss: gastroplasty, duodenal sleeves, intragastric balloons, and aspiration, World J Gastrointest Endosc, 7, pp. 847-859, (2015)
[8]  
Zheng Y., Wang M., He S., Ji G., Short-term effects of intragastric balloon in association with conservative therapy on weight loss: a meta-analysis, J Transl Med, 13, (2015)
[9]  
Angrisani L., Lorenzo M., Borrelli V., Giuffre M., Fonderico C., Capece G., Is bariatric surgery necessary after intragastric balloon treatment?, Obes Surg, 16, pp. 1135-1137, (2006)
[10]  
Nguyen N., Champion J.K., Ponce J., Quebbemann B., Patterson E., Pham B., Raum W., Buchwald J.N., Segato G., Favretti F., A review of unmet needs in obesity management, Obes Surg, 22, pp. 956-966, (2012)
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