Metabolic control and diabetic retinopathy in patients with diabetes type 2; [Stoffwechselkontrolle und diabetische Retinopathie bei Patienten mit Typ-2-Diabetes]

被引：0

作者：

Kosanović-Jaković N. ^{[1
]}

Resan M. ^{[2
]}

Dimitrijević-Srećković V. ^{[3
]}

Vukosavljević M. ^{[2
]}

Milenković S. ^{[1
]}

Čolak E. ^{[4
]}

Risović D. ^{[1
]}

Avramović S. ^{[2
]}

Canović F. ^{[3
]}

机构：

[1] Institute of Ophthalmology, University Clinical Center of Serbia, Belgrade

[2] Eye Clinic, Military Medical Academy Belgrade, 11000 Belgrade

[3] Institute of Endocrinology, Diabetes and Metabolic Disorders, University Clinical Center of Serbia, Belgrade

[4] Institute of Medical Biochemistry, University Clinical Center of Serbia, Belgrade

来源：

Spektrum der Augenheilkunde | 2010年 / 24卷 / 3期

关键词：

Diabetes type 2; Diabetic retinopathy; Glycosylated hemoglobin; High-density lipoprotein cholesterol; Metabolic control;

D O I：

10.1007/s00717-010-0399-5

中图分类号：

学科分类号：

摘要：

AIM: To evaluate the correlation between metabolic control and the presence and severity level of diabetic retinopathy (DR) in patients with diabetes type 2. METHODS: This cross-sectional study included 80 patients divided into four groups according to the duration of the disease: de novo; up to 10 years; from 11 to 20 years; and over 20 years. In order to evaluate the metabolic control each patient was tested for: glycosylated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). According to eye fundus changes patients were classified following the American Academy of Ophthalmology classification. RESULTS: The patients with DR had significantly increased values of HbA1c. (9.5 ± 1.83%) and decreased values of HDL-C (1.1 ± 0.21 mmol/L) compared to patients without DR (6.9 ± 1.29%, t = 5.088; p < 0,001) and (1.3 ± 0.25 mmol/L, t = 3.022; p < 0.01) respectively. The presence and severity level of DR correlated positively with HbA1c values (p < 0.001) and poor glycaemic control (p < 0.001) while HDL-C values correlated inversely with the presence (p < 0.01) and severity level of DR (p < 0.05). CONCLUSION: Poor metabolic control determined by the increased values of HbA1cand decreased values of HDL-C correlates with the presence and severity of DR. © 2010 Springer-Verlag.

引用

页码：157 / 161

页数：4

共 18 条

[1]

Stur M., Eggert S., Hass A., Kieselbach G., Mennel S., Michlo R., Et al., Praxis-Richtlinien der Österreichischen Diabetesgesellschaft (Update Juni 2006) Diagnose, Therapie und Verlaufskontrolle der diabetischen Augenerkrankung, Spektrum Augenheilkd, 20, 5, pp. 234-240, (2006)

[2]

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33), Lancet, 352, 9131, pp. 837-853, (1998)

[3]

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34), Lancet, 352, 9131, pp. 854-865, (1998)

[4]

Stratton I.M., Adler A.I., Neil H.A., Matthews D.R., Manley S.E., Cull C.A., Et al., Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study, Bmj, 321, 7258, pp. 405-412, (2000)

[5]

Leiter L.A., The prevention of diabetic microvascular complications of diabetes: Is there a role for lipid lowering?, Diabetes Res Clin Pract, 68, SUPPL. 2, (2005)

[6]

Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report, Circulation, 106, 25, pp. 3143-3421, (2002)

[7]

International Clinical Diabetic Retinopathy Disease Severity Scale, International Council of Ophthalmology Web-site, (2002)

[8]

Fong D.S., Aiello L., Gardner T.W., King G.L., Blankenship G., Cavallerano J.D., Et al., Retinopathy in Diabetes, Diabetes Care, 27, SUPPL. 1, (2004)

[9]

Wan Nazaimoon W.M., Letchuman R., Noraini N., Ropilah A.R., Zainal M., Ismail I.S., Et al., Systolic hypertension and duration of diabetes mellitus are important determinants of retinopathy and microalbuminuria in young diabetics, Diabetes Res Clin Pract, 46, 3, pp. 213-221, (1999)

[10]

Tapp R.J., Shaw J.E., Harper C.A., de Courten M.P., Balkau B., McCarty D.J., Et al., The prevalence of and factors associated with diabetic retinopathy in the Australian population, Diabetes Care, 26, 6, pp. 1731-1737, (2003)

← 1 2 →