Abnormal Functional Connectivity Density in Post-traumatic Stress Disorder

被引：0
作者：
Youxue Zhang
Bing Xie
Heng Chen
Meiling Li
Feng Liu
Huafu Chen
机构：
[1] University of Electronic Science and Technology of China,Center for Information in BioMedicine, Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology
[2] Third Military Medical University,Department of Anatomy
[3] Tianjin Medical University General Hospital,Department of Radiology and Tianjin Key Laboratory of Functional Imaging
来源：
Brain Topography | 2016年 / 29卷
关键词：
Post-traumatic stress disorder; Functional connectivity density; Dorsolateral prefrontal cortex;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Post-traumatic stress disorder (PTSD) is a psychiatric disorder that occurs in individuals who have experienced life-threatening mental traumas. Previous neuroimaging studies have indicated that the pathology of PTSD may be associated with the abnormal functional integration among brain regions. In the current study, we used functional connectivity density (FCD) mapping, a novel voxel-wise data-driven approach based on graph theory, to explore aberrant FC through the resting-state functional magnetic resonance imaging of the PTSD. We calculated both short- and long-range FCD in PTSD patients and healthy controls (HCs). Compared with HCs, PTSD patients showed significantly increased long-range FCD in the left dorsolateral prefrontal cortex (DLPFC), but no abnormal short-range FCD was found in PTSD. Furthermore, seed-based FC analysis of the left DLPFC showed increased connectivity in the left superior parietal lobe and visual cortex of PTSD patients. The results suggested that PTSD patients experienced a disruption of intrinsic long-range functional connections in the fronto-parietal network and visual cortex, which are associated with attention control and visual information processing.
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页码：405 / 411
页数：6
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