Epidemiology of anti-tuberculosis drug resistance patterns and trends in tuberculosis referral hospital in Addis Ababa, Ethiopia

被引：38
作者：
Abate D. [1 ,2 ]
Taye B. [1 ,3 ]
Abseno M. [2 ]
Biadgilign S. [4 ]
机构：
[1] Addis Ababa University, College of Health Science, School of Medical Laboratory Sciences, Addis Ababa
[2] St. Peters TB Specialized Hospital, Addis Ababa
[3] Addis Ababa University, College of Health Science, School of Public Health, Addis Ababa
[4] Department of Epidemiology and Biostatistics, Jimma University, College of Public Health and Medical Science, Jimma
来源：
BMC Research Notes | / 5卷 / 1期
关键词：
Drug resistance; Drug susceptibility; Epidemiology; MDR-TB; Trend;
D O I：
10.1186/1756-0500-5-462
中图分类号：
学科分类号：
摘要：
Background: Drug-resistant TB has emerged as a major challenge facing TB prevention and control efforts. In Ethiopia, the extent/trend of drug resistance TB is not well known. The aim of this study was to determine the pattern and trend of resistance to first line anti-TB drugs among culture positive retreatment cases at St.Peters TB Specialized Hospital. Findings. A hospital based retrospective study was used to assess the pattern of anti-TB drug resistance among previously treated TB patients referred to St.Peters TB Specialized Hospital from January 2004-December 2008 Gregorian calendar(GC) for better diagnosis and treatment. Among 376 culture positive for M. tuberculosis one hundred and two (27.1%) were susceptible to all of the four first line anti-TB drugs -Isoniazid (INH), Rifampicin (RIF), Ethambutol (ETB) & Streptomycin (STM). While 274 (72.9%) were resistant to at least one drug. Any resistance to STM (67.3%) was found to be the most common and the prevalence of MDR-TB was 174 (46.3%). Trend in resistance rate among re-treatment cases from 2004 to 2008 showed a significant increase for any drug as well as for INH, RIF, and MDR resistance (P <0.05 for trend). Conclusions: There has been an increasing trend in drug resistance in recent years, particularly in retreatment cases. Therefore, establishing advanced diagnostic facilities for early detection of MDR-TB and expanding second line treatment center to treat MDR-TB patients and to prevent its transmission is recommended. © 2012 Abate et al.; licensee BioMed Central Ltd.
引用
收藏
相关论文
共 27 条
  • [1] World Health Organization: Global Tuberculosis Control: Surveillance, Planning and Financing, (2008)
  • [2] World Health Organization: Global Tuberculosis Control: WHO Report 2011, (2011)
  • [3] Demissie M.L.B., Tegbaru B., Human Immunodeficiency virus (HIV) infection in tuberculosis patients in Addis Ababa, Ethiop J Health Dev, 14, pp. 277-282, (2000)
  • [4] Guideline for Program and Clinical Management of Drug Resistant Tuberculosis, (2009)
  • [5] Multidrug and Extensively Drug-resistant TB (M/XDR-TB): 2010 Global Report on Surveillance and Response, (2010)
  • [6] Wilkinson L.S.R., Extensively drug resistant tuberculosis, BMJ, 333, 7568, pp. 559-560, (2006)
  • [7] Juan C., Palomino S.C., Viviana R., Tuberculosis 2007 from Basic Science to Patient Care, pp. 635-636, (2007)
  • [8] Addressing the threat of tuberculosis caused by extensively drug-resistant Mycobacterium tuberculosis, Wkly Epidemiol Rec, 81, pp. 386-390, (2006)
  • [9] Raviglione Mc D.C., Schmidt S., Kochi A., Assessment of world-wide tuberculosis control, Lancet, 350, pp. 624-629, (1997)
  • [10] Health E., TB Laboratory Standard Operating Procedure (SOP), (2007)
123