Inhibitory effects of 2-(4-chlorophenyl)-1,3-selenazol-4-one on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells

被引：0
作者：
Sang Yoon Choi
Yeon Ock Jo
Mamoru Koketsu
Hideharu Ishihara
Sung Hoon Kim
Sun Yeou Kim
机构：
[1] Korea Food Research Institute,Division of Strategic Program
[2] Gifu University,Division of Instrumental Analysis, Life Science Research Center
[3] Gifu University,Department of Chemistry
[4] Kyunghee University,Cancer Preventive Material Development Research Center
[5] Kyunghee University,Graduate School of East
来源：
Journal of the Korean Society for Applied Biological Chemistry | 2009年 / 52卷
关键词：
iNOS; macrophage; nitric oxide; selenium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this study, the inhibitory effects of selenium-containing heterocyclic compound, selenazol derivatives on LPS-induced nitric oxide production in macrophage cells (RAW 264.7) were assessed. Five kinds of selenazol derivatives were shown to exhibit 5.4∼41.7% of inhibitory effects at 10 μM. Among them, 2-(4-chlorophenyl)-l,3-selenazol-4-one generally evidenced a high degree of inhibitory activity with IC50=11.8 μM, and this compound also profoundly suppressed iNOS expression in LPS-treated RAW 264.7 cells. These results indicated that 2-(4-chlorophenyl)-l,3-selenazol-4-one might function as an anti-inflammatory agent via the inhibition of iNOS-mediated nitric oxide production.
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页码：371 / 374
页数：3
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