Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity

被引：0
|
作者：
Adrian Tun-Kyi
Greg Finn
Alex Greenwood
Michael Nowak
Tae Ho Lee
John M Asara
George C Tsokos
Kate Fitzgerald
Elliot Israel
Xiaoxia Li
Mark Exley
Linda K Nicholson
Kun Ping Lu
机构：
[1] Beth Israel Deaconess Medical Center,Department of Medicine
[2] Harvard Medical School,Department of Molecular Biology and Genetics
[3] Cornell University,Division of Infectious Diseases and Immunology
[4] University of Massachusetts Medical School,Department of Medicine
[5] Brigham and Women's Hospital,Department of Immunology
[6] Cleveland Clinic Foundation,undefined
来源：
Nature Immunology | 2011年 / 12卷
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摘要：
The protein isomerase Pin1 regulates the conformational state of signaling proteins. Lu and colleagues show that Pin1 has an essential role in Toll-like receptor signaling by regulating the adapter IRAK1.
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收藏
页码：733 / 741
页数：8
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