Acidic Microclimate pH Distribution in PLGA Microspheres Monitored by Confocal Laser Scanning Microscopy

[1] Schwendeman S. P.(2002)Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems Crit. Rev. Ther. Drug Carrier Sys 19 73-98

[2] Langer R.(1993)Tissue engineering Science 260 920-926

[3] Vacanti J. P.(1996)Controlled release of a therapeutic protein Nat. Med 2 742-743

[4] Langer R.(1997)Biological erodable microspheres as potential oral delivery systems Nature 386 410-414

[5] Mathiowitz E.(1996)A month-long effect from a single injection of microencapsulated human growth hormone Nat. Med 2 795-799

[6] Jacob J.(1995)Biodegradable microspheres in drug delivery Crit. Rev. Ther. Drug Carrier Sys 12 1-99

[7] Jong Y.(1997)One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate Adv. Drug Del. Rev 28 43-70

[8] Carino G.(2000)Protein stability in controlled-release systems Nat Biotechnol 18 24-25

[9] Chickering D.(1998)Improved protein therapeutics with sustained-release formulations Nat. Biotechnol 16 478-157

[10] Chaturvedi P.(1998)Improved protein therapeutic with sustained-release formulations Nat. Biotechnol 16 153-1288

[1] Schwendeman S. P.(2002)Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems Crit. Rev. Ther. Drug Carrier Sys 19 73-98

[2] Langer R.(1993)Tissue engineering Science 260 920-926

[3] Vacanti J. P.(1996)Controlled release of a therapeutic protein Nat. Med 2 742-743

[4] Langer R.(1997)Biological erodable microspheres as potential oral delivery systems Nature 386 410-414

[5] Mathiowitz E.(1996)A month-long effect from a single injection of microencapsulated human growth hormone Nat. Med 2 795-799

[6] Jacob J.(1995)Biodegradable microspheres in drug delivery Crit. Rev. Ther. Drug Carrier Sys 12 1-99

[7] Jong Y.(1997)One- and three-month release injectable microspheres of the LH-RH superagonist leuprorelin acetate Adv. Drug Del. Rev 28 43-70

[8] Carino G.(2000)Protein stability in controlled-release systems Nat Biotechnol 18 24-25

[9] Chickering D.(1998)Improved protein therapeutics with sustained-release formulations Nat. Biotechnol 16 478-157

[10] Chaturvedi P.(1998)Improved protein therapeutic with sustained-release formulations Nat. Biotechnol 16 153-1288