Neuropharmacologic targets and agents in fibromyalgia.

被引：0
作者：
Suzuki R. [1 ]
Dickenson A.H. [1 ]
机构：
[1] Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London
来源：
Current Pain and Headache Reports | 2002年 / 6卷 / 4期
关键词：
NMDA Receptor; Neuropathic Pain; Fibromyalgia; Dorsal Horn; Memantine;
D O I：
10.1007/s11916-002-0047-0
中图分类号：
学科分类号：
摘要：
Chronic widespread pain is a primary feature of fibromyalgia and is a symptom that is poorly managed in many patients. In addition, patients often experience fatigue, sleep disturbances, and anxiety. Its etiology is largely unknown. The successful clinical management of this syndrome relies on a multidisciplinary approach, employing pharmacologic and nonpharmacologic treatments. Clinical evidence on the symptoms and characteristics of fibromyalgia suggests a central mechanism behind the pathogenesis of this syndrome. It is likely that drugs with central actions will prove to be effective against a number of symptoms. This article aims to outline some of the potential spinal pharmacologic targets that may be used to treat this condition.
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页码：267 / 273
页数：6
相关论文
共 122 条
[1]  
Yunus M(1989)Short term benefits of ibuprofen in primary fibromyalgia syndrome: a double blind placebo controlled trial J Rheumatol 16 527-532
[2]  
Masi A(2001)Fibromyalgia Syndrome: a new paradigm for differential diagnosis and treatment J Manipulative Physiol Ther 24 529-541
[3]  
Aldag J(1998)Increased capsaicin-induced secondary hyperalgesia as a marker of abnormal sensory activity in patients with fibromyalgia Neurosci Lett 250 205-207
[4]  
Schneider M(1988)Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis Pain 32 21-26
[5]  
Brady D(2000)Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways Pain 87 201-211
[6]  
Morris V(2001)Effects of spinally delivered N- and P-type voltage-dependent calcium channel antagonists on dorsal horn neuronal responses in a rat model of neuropathy Pain 92 235-246
[7]  
Cruwys S(2000)Effects of antagonists to high-threshold calcium channels upon spinal mechanisms of pain, hyperalgesia and allodynia Pain 85 9-18
[8]  
Kidd B(1988)Calcium ions, active zones and synaptic transmitter release Trends Neurosci 11 458-464
[9]  
Vaeroy H(1998)Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial JAMA 280 1831-1836
[10]  
Helle R(1998)Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial JAMA 280 1837-1842
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