Inherited human IRAK-4 deficiency: an update

被引：0

作者：

Capucine Picard

Horst von Bernuth

Cheng-Lung Ku

Kun Yang

Anne Puel

Jean-Laurent Casanova

机构：

[1] Hôpital Necker-Enfants Malades,Centre d’étude des déficits immunitaires

[2] Institut National de la Santé et de la Recherche Médicale,Laboratoire de Génétique Humaine des Maladies Infectieuses

[3] U550,Université Paris Descentes

[4] Faculte Médecine Necker,Unité d’Immunologie et d’Hématologie Pédiatriques

[5] Hôpital Necker-Enfants Malades,undefined

来源：

Immunologic Research | 2007年 / 38卷

关键词：

Primary immunodeficiency; NF-κB; Toll-like receptors; Interleukin-1 receptors; Tumor necrosis factor receptors; Inflammation;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.

引用

页码：347 / 352

页数：5