Inherited human IRAK-4 deficiency: an update

被引：0
作者：
Capucine Picard
Horst von Bernuth
Cheng-Lung Ku
Kun Yang
Anne Puel
Jean-Laurent Casanova
机构：
[1] Hôpital Necker-Enfants Malades,Centre d’étude des déficits immunitaires
[2] Institut National de la Santé et de la Recherche Médicale,Laboratoire de Génétique Humaine des Maladies Infectieuses
[3] U550,Université Paris Descentes
[4] Faculte Médecine Necker,Unité d’Immunologie et d’Hématologie Pédiatriques
[5] Hôpital Necker-Enfants Malades,undefined
来源：
Immunologic Research | 2007年 / 38卷
关键词：
Primary immunodeficiency; NF-κB; Toll-like receptors; Interleukin-1 receptors; Tumor necrosis factor receptors; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.
引用
收藏
页码：347 / 352
页数：5
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