Inherited human IRAK-4 deficiency: an update

被引：0
作者：
Capucine Picard
Horst von Bernuth
Cheng-Lung Ku
Kun Yang
Anne Puel
Jean-Laurent Casanova
机构：
[1] Hôpital Necker-Enfants Malades,Centre d’étude des déficits immunitaires
[2] Institut National de la Santé et de la Recherche Médicale,Laboratoire de Génétique Humaine des Maladies Infectieuses
[3] U550,Université Paris Descentes
[4] Faculte Médecine Necker,Unité d’Immunologie et d’Hématologie Pédiatriques
[5] Hôpital Necker-Enfants Malades,undefined
来源：
Immunologic Research | 2007年 / 38卷
关键词：
Primary immunodeficiency; NF-κB; Toll-like receptors; Interleukin-1 receptors; Tumor necrosis factor receptors; Inflammation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interleukin-1 receptor-associated kinase-4 (IRAK-4), a member of the IRAK family, plays an essential role in Toll-like receptor- and IL-1 receptor-mediated signaling. We briefly review inherited human IRAK-4 deficiency, a recently described primary immunodeficiency leading to recurrent, invasive, pyogenic bacteria infection, and invasive pneumococcal disease in particular.
引用
收藏
页码：347 / 352
页数：5
相关论文
共 50 条
  • [1] Inherited human IRAK-4 deficiency: an update
    Picard, Capucine
    von Bernuth, Horst
    Ku, Cheng-Lung
    Yang, Kun
    Puel, Anne
    Casanova, Jean-Laurent
    IMMUNOLOGIC RESEARCH, 2007, 38 (1-3) : 347 - 352
  • [2] IRAK-4 deficiency as a cause for familial fatal invasive infection by Streptococcus pneumoniae
    Grazioli, Serge
    Hamilton, Sara J.
    McKinnon, Margaret L.
    Del Bel, Kate L.
    Hoang, Linda
    Cook, Victoria E.
    Hildebrand, Kyla J.
    Junker, Anne K.
    Turvey, Stuart E.
    CLINICAL IMMUNOLOGY, 2016, 163 : 14 - 16
  • [3] Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis
    Wiese, Michael D.
    Manning-Bennett, Arkady T.
    Abuhelwa, Ahmad Y.
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2020, 29 (05) : 475 - 482
  • [4] Emerging trends in IRAK-4 kinase research
    Yadav, Himanshu
    Shirumalla, Raj Kumar
    MOLECULAR BIOLOGY REPORTS, 2023, 50 (09) : 7825 - 7837
  • [5] Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency
    Picard, Capucine
    Casanova, Jean-Laurent
    Puel, Anne
    CLINICAL MICROBIOLOGY REVIEWS, 2011, 24 (03) : 490 - 497
  • [6] Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia
    Garcia-Garcia, Ana
    de Diego, Rebeca Perez
    Flores, Carlos
    Rinchai, Darawan
    Sole-Violan, Jordi
    Deya-Martinez, Angela
    Garcia-Solis, Blanca
    Lorenzo-Salazar, Jose M.
    Hernandez-Brito, Elisa
    Lanz, Anna-Lisa
    Moens, Leen
    Bucciol, Giorgia
    Almuqamam, Mohamed
    Domachowske, Joseph
    Colino, Elena
    Santos-Perez, Juan Luis
    Marco, Francisco
    Pignata, Claudio
    Bousfiha, Aziz
    Turvey, Stuart
    Bauer, Stefanie
    Haerynck, Filomeen
    Ocejo-Vinyals, Javier Gonzalo
    Lendinez, Francisco
    Prader, Seraina
    Naumann-Bartsch, Nora
    Pachlopnik Schmid, Jana
    Biggs, Catherine
    Hildebrand, Kyla
    Dreesman, Alexandra
    Cardenes, Miguel Angel
    Ailal, Fatima
    Benhsaien, Ibtihal
    Giardino, Giuliana
    Molina-Fuentes, Agueda
    Fortuny, Claudia
    Madhavarapu, Swetha
    Conway, Daniel
    Prando, Carolina
    Schidlowski, Laire
    Alvarez, Maria Teresa Martinez de Saavedra
    Alfaro, Rafael
    de Castro, Felipe Rodriguez
    Meyts, Isabelle
    Hauck, Fabian
    Puel, Anne
    Bastard, Paul
    Boisson, Bertrand
    Jouanguy, Emmanuelle
    Abel, Laurent
    JOURNAL OF EXPERIMENTAL MEDICINE, 2023, 220 (05)
  • [7] IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses
    Lye, Elizabeth
    Dhanji, Salim
    Calzascia, Thomas
    Elford, Alisha R.
    Ohashi, Pamela S.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (03) : 870 - 876
  • [8] IRAK-4 inhibitors. Part 1: A series of amides
    Buckley, George M.
    Gowers, Lewis
    Higueruelo, Alicia Perez
    Jenkins, Kerry
    Mack, Stephen R.
    Morgan, Trevor
    Parry, David M.
    Pitt, William R.
    Rausch, Oliver
    Richard, Marianna D.
    Sabin, Verity
    Fraser, Joanne L.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (11) : 3211 - 3214
  • [9] Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts
    Della Mina, Erika
    Borghesi, Alessandro
    Zhou, Hao
    Bougarn, Salim
    Boughorbel, Sabri
    Israel, Laura
    Meloni, Ilaria
    Chrabieh, Maya
    Ling, Yun
    Itan, Yuval
    Renieri, Alessandra
    Mazzucchelli, Iolanda
    Basso, Sabrina
    Pavone, Piero
    Falsaperla, Raffaele
    Ciccone, Roberto
    Cerbo, Rosa Maria
    Stronati, Mauro
    Picard, Capucine
    Zuffardi, Orsetta
    Abel, Laurent
    Chaussabel, Damien
    Marr, Nico
    Li, Xiaoxia
    Casanova, Jean-Laurent
    Puel, Anne
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (04) : E514 - E523
  • [10] IRAK-4 inhibition: emavusertib for the treatment of lymphoid and myeloid malignancies
    Parrondo, Ricardo D.
    Iqbal, Madiha
    Von Roemeling, Reinhard
    Von Roemeling, Christina
    Tun, Han W.
    FRONTIERS IN IMMUNOLOGY, 2023, 14
12345