Inhibition of human ovarian tumor growth by cytokine-induced killer cells

被引：0

作者：

Hwan Mook Kim

Jong Soon Kang

Jaeseung Lim

Song-Kyu Park

Kiho Lee

Yeo Dae Yoon

Chang Woo Lee

Ki Hoon Lee

Gyoonhee Han

Kyu-Hwan Yang

Yeon Jin Kim

Youngsoo Kim

Sang-Bae Han

机构：

[1] Korea Research Institute of Bioscience and Biotechnology (KRIBB),Bioevaluation Center

[2] Innocell Ltd.,Department of Biotechnology

[3] Yonsei University,College of Pharmacy and CBITRC

[4] Kyungwon University,undefined

[5] Chungbuk National University,undefined

来源：

Archives of Pharmacal Research | 2007年 / 30卷

关键词：

Cytokine-induced killer cells; Ovarian cancer; Adoptive immunotherapy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluatedin vitro andin vivo. Although CD3+CD56+ cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.

引用

页码：1464 / 1470

页数：6

共 198 条

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