DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

被引：0

作者：

Olga A Guryanova

Kaitlyn Shank

Barbara Spitzer

Luisa Luciani

Richard P Koche

Francine E Garrett-Bakelman

Chezi Ganzel

Benjamin H Durham

Abhinita Mohanty

Gregor Hoermann

Sharon A Rivera

Alan G Chramiec

Elodie Pronier

Lennart Bastian

Matthew D Keller

Daniel Tovbin

Evangelia Loizou

Abby R Weinstein

Adriana Rodriguez Gonzalez

Yen K Lieu

Jacob M Rowe

Friederike Pastore

Anna Sophia McKenney

Andrei V Krivtsov

Wolfgang R Sperr

Justin R Cross

Christopher E Mason

Martin S Tallman

Maria E Arcila

Omar Abdel-Wahab

Scott A Armstrong

Stefan Kubicek

Philipp B Staber

Mithat Gönen

Elisabeth M Paietta

Ari M Melnick

Stephen D Nimer

Siddhartha Mukherjee

Ross L Levine

机构：

[1] Human Oncology and Pathogenesis Program,Department of Pediatrics

[2] Memorial Sloan Kettering Cancer Center,Division of Hematology and Oncology, Department of Medicine

[3] Memorial Sloan Kettering Cancer Center,Department of Hematology

[4] University of Miami Sylvester Comprehensive Cancer Center,Department of Laboratory Medicine

[5] Center for Epigenetics Research,Division of Hematology and Hemostaseology

[6] Memorial Sloan Kettering Cancer Center,Department of Physiology and Biophysics and the Institute for Computational Biomedicine

[7] Cancer Biology and Genetics Program,Department of Medicine

[8] Memorial Sloan Kettering Cancer Center,Department of Epidemiology and Biostatistics

[9] Weill Cornell Medicine,Department of Oncology

[10] Shaare Zedek Medical Center,undefined

[11] Diagnostic Molecular Pathology Laboratory,undefined

[12] Memorial Sloan Kettering Cancer Center,undefined

[13] Medical University of Vienna,undefined

[14] Irving Cancer Research Center,undefined

[15] Columbia University,undefined

[16] Comprehensive Cancer Center Vienna,undefined

[17] Medical University of Vienna,undefined

[18] Donald B. and Catherine C. Marron Cancer Metabolism Center,undefined

[19] Memorial Sloan Kettering Cancer Center,undefined

[20] Weill Cornell Medical College of Cornell University,undefined

[21] Leukemia Service,undefined

[22] Memorial Sloan Kettering Cancer Center,undefined

[23] Center for Hematologic Malignancies,undefined

[24] Memorial Sloan Kettering Cancer Center,undefined

[25] Christian Doppler Laboratory for Chemical Genetics and Anti-Infectives,undefined

[26] CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences,undefined

[27] Memorial Sloan Kettering Cancer Center,undefined

[28] Montefiore Medical Center,undefined

来源：

Nature Medicine | 2016年 / 22卷

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中图分类号：

学科分类号：

摘要：

AML cells carrying R882 mutations in DNMT3A fail to sense and repair DNA damage induced by standard-dose chemotherapy as a result of impaired chromatin remodeling

引用

页码：1488 / 1495

页数：7

共 76 条

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