Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

被引：0
作者：
Akiko Hayashi-Takagi
Manabu Takaki
Nick Graziane
Saurav Seshadri
Hannah Murdoch
Allan J Dunlop
Yuichi Makino
Anupamaa J Seshadri
Koko Ishizuka
Deepak P Srivastava
Zhong Xie
Jay M Baraban
Miles D Houslay
Toshifumi Tomoda
Nicholas J Brandon
Atsushi Kamiya
Zhen Yan
Peter Penzes
Akira Sawa
机构：
[1] Johns Hopkins University School of Medicine,Department of Psychiatry
[2] University at Buffalo,Department of Physiology and Biophysics
[3] State University of New York,Department of Neuroscience
[4] Neuroscience and Molecular Pharmacology,Department of Physiology
[5] Faculty of Biomedical and Life Sciences,undefined
[6] University of Glasgow,undefined
[7] Johns Hopkins University School of Medicine,undefined
[8] Northwestern University Feinberg School of Medicine,undefined
[9] Beckman Research Institute of the City of Hope,undefined
[10] Pfizer,undefined
来源：
Nature Neuroscience | 2010年 / 13卷
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摘要：
The number of dendritic spines is reduced in the postmortem brains of individuals with schizophrenia. Revealing a potential mechanism of such change, this study finds that the schizophrenia-associated protein DISC1 regulates the Rho GTPase pathway to modulate dendritic spine size.
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页码：327 / 332
页数：5
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