Densitometric Determination of Desloratadine in Tablets, and Validation of the Method

被引：0

作者：

Endang Sumarlik

Hoshi Berniati Tampubolon

Mochammad Yuwono

Gunawan Indrayanto

机构：

[1] QC Laboratory,Assessment Service Unit, Faculty of Pharmacy

[2] Bernofarm Pharmaceutical Company,undefined

[3] Buduran,undefined

[4] Sidoarjo,undefined

[5] Airlangga University,undefined

来源：

JPC – Journal of Planar Chromatography – Modern TLC | 2005年 / 18卷

关键词：

TLC; Densitometry; Tablet; Validation; Desloratadine;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A simple and rapid densitometric method has been developed for determination of desloratadine in tablets. After extraction of the samples with 96% ethanol the solutions were spotted on precoated silica gel TLC plates and these were eluted with ethyl acetate–n-butanol–25% aqueous ammonia–methanol, 21 + 5.0 + 4.0 + 5.0 (v/v), as mobile phase. Quantitative evaluation was performed by measuring the absorbance reflectance of the desloratadine spots at λ = 279 nm. The TLC–densitometric method is selective, precise, and accurate and can be used for routine analysis of tablets in pharmaceutical industry quality control laboratories.

引用

页码：19 / 22

页数：3