Catch of the day: zebrafish as a human cancer model

被引：0
作者：
K Stoletov
R Klemke
机构：
[1] University of California at San Diego,Department of Pathology
[2] Moores Cancer Center,undefined
[3] University of California at San Diego,undefined
来源：
Oncogene | 2008年 / 27卷
关键词：
zebrafish; cancer; metastasis; angiogenesis; xenotransplantant; transgenic;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemia, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field.
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页码：4509 / 4520
页数：11
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共 302 条
[11]  
Sadler KC(2008)Genomic analysis of metastasis reveals an essential role for RhoC Oncogene 27 1079-175
[12]  
Lai K(2007)Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development Br J Haematol 138 169-64
[13]  
Farrington S(2000)Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish Cell Mol Life Sci 57 41-84
[14]  
Bronson RT(2007)The biology of cell locomotion within three-dimensional extracellular matrix Microvasc Res 74 72-2479
[15]  
Lees JA(2007)Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization J Clin Oncol 25 2473-553
[16]  
Beckwith LG(2007)New waves of discovery: modeling cancer in zebrafish Nat Methods 4 551-1979
[17]  
Moore JL(2005)Ultrasound biomicroscopy permits Genes Dev 19 1974-151
[18]  
Tsao-Wu GS(2005) characterization of zebrafish liver tumors Angiogenesis 9 139-59
[19]  
Harshbarger JC(2007)RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis BMC Dev Biol 7 42-449
[20]  
Cheng KC(2006)Human melanoma cells transplanted into zebrafish proliferate, migrate, produce melanin, form masses and stimulate angiogenesis in zebrafish EMBO Rep 7 444-133
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