Catch of the day: zebrafish as a human cancer model

被引：0
作者：
K Stoletov
R Klemke
机构：
[1] University of California at San Diego,Department of Pathology
[2] Moores Cancer Center,undefined
[3] University of California at San Diego,undefined
来源：
Oncogene | 2008年 / 27卷
关键词：
zebrafish; cancer; metastasis; angiogenesis; xenotransplantant; transgenic;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Zebrafish are making big waves in the field of cancer research. The effect has been widespread and continues to gain speed as more and more cancer researchers ride the wave of zebrafish biology. This has been largely due to the development of transgenic and xenograft models of cancer, which recapitulate many aspects of different human cancers including lymphoblastic T-cell leukemia, pancreatic cancer, melanoma and rhabdomyosarcoma. These models are already being utilized by academia and industry to search for genetic and chemical modifiers of cancer with success. The attention has been further stimulated by the amenability of zebrafish to pharmacological testing and the superior imaging properties of fish tissues that allow visualization of cancer progression and angiogenesis in live animals. This review summarizes the current zebrafish models of cancer and discusses their utility in human cancer research and future directions in the field.
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页码：4509 / 4520
页数：11
相关论文
共 302 条
[1]  
Ablooglu AJ(2007)The zebrafish vitronectin receptor: characterization of integrin alphaV and beta3 expression patterns in early vertebrate development Dev Dyn 236 2268-2276
[2]  
Kang J(2002)Zebrafish as a cancer model system Cancer Cell 3 229-231
[3]  
Handin RI(2004)Many ribosomal protein genes are cancer genes in zebrafish PLoS Biol 2 E139-385
[4]  
Traver D(2000)Ethylnitrosourea induces neoplasia in zebrafish ( Lab Invest 80 379-112
[5]  
Shattil SJ(2006)) Trends Cell Biol 16 105-237
[6]  
Amatruda JF(2005) cell biology: following the zebrafish trend Biotechniques 39 227-412
[7]  
Shepard JL(2005)Making waves in cancer research: new models in the zebrafish Proc Natl Acad Sci USA 102 407-157
[8]  
Stern HM(1999)tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors Cell 198 147-471
[9]  
Zon LI(2007)Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis Leukemia 21 462-535
[10]  
Amsterdam A(2000)NOTCH1-induced T-cell leukemia in transgenic zebrafish Nature 406 532-1086
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