Notch Signaling and Bone Remodeling

被引：0
作者：
Jenna Regan
Fanxin Long
机构：
[1] Washington University School of Medicine,Department of Medicine
[2] Washington University School of Medicine,Department of Developmental Biology
来源：
Current Osteoporosis Reports | 2013年 / 11卷
关键词：
Notch signaling; Bone remodeling; Osteoblasts; Osteoclasts; Skeletal development; Skeletal diseases; Hajdu-Cheney syndrome; Alagille syndrome;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Notch signaling plays context-dependent roles in the development and maintenance of many cell types and tissues in mammals. In the skeleton, both osteoblasts and osteoclasts require Notch signaling for proper differentiation and function, and the specific roles of Notch are dependent on the differentiation status of the cell. The recent discovery of activating NOTCH2 mutations as the cause of Hajdu-Cheney syndrome has highlighted the significance of Notch signaling in human bone physiology.
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页码：126 / 129
页数：3
相关论文
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