Obesity and Cancer—Opportunities to Break the Link

被引：3
作者：
Argolo D.F. [1 ,3 ]
Hudis C.A. [1 ,2 ]
Iyengar N.M. [1 ,2 ]
机构：
[1] Memorial Sloan Kettering Cancer Center, 300 East 66th Street – 8th floor, New York, 10065, NY
[2] Weill Cornell Medical College, New York, NY
[3] CLION - CAM group, Salvador, BA
来源：
Current Breast Cancer Reports | 2016年 / 8卷 / 1期
关键词：
Adipose tissue; Breast cancer; Cancer; Inflammation; Insulin; Metabolic syndrome; Obesity; Translational research;
D O I：
10.1007/s12609-016-0200-0
中图分类号：
学科分类号：
摘要：
Obesity is a major global health problem with a rising worldwide burden. In addition to its association with several diseases, obesity is associated with increased incidence and worse prognosis for many malignances. Many possible mechanisms that contribute to the obesity-cancer link have been proposed, but key pathways likely include steroid hormone signaling, altered gut microbiota, insulin and insulin growth factor interactions, levels of circulating adipokines, and local and systemic inflammation. By understanding these mechanisms and their interactions, we may be able to intervene to improve the public health burden imposed by obesity. Equally critical to the development of targeted intervention strategies is the identification of accurate biomarkers to better detect populations that are more or less likely to benefit from specific interventions. © 2016, Springer Science+Business Media New York.
引用
收藏
页码：22 / 31
页数：9
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