Gonadotropin-releasing hormone agonists administration in polycystic ovary syndrome. Effects on bone mass

被引：0
作者：
Giovanni Lupoli
C. Di Carlo
V. Nuzzo
G. Vitale
D. Russo
S. Palomba
C. Nappi
机构：
[1] Università “Federico II”,Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica
[2] Università “Federico II”,Cattedra di Ginecologia ed Ostetricia, Facoltà di Medicina e Chirurgia
来源：
Journal of Endocrinological Investigation | 1997年 / 20卷
关键词：
Gonadotropin-releasing hormone agonists; polycystic ovary syndrome; bone mineral density; osteoporosis; osteopenia;
D O I：
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中图分类号：
学科分类号：
摘要：
Women with amenorrhea and polycystic ovaries (PCO) seem to present a relative degree of protection against bone loss caused by hypoestrogenism. We treated 20 patients affected by polycystic ovary syndrome (PCOS) with a gonadotropin-releasing hormone agonist (GnRH-a) for 6 months. After treatment mean bone mineral density (BMD) significantly decreased. We concluded that patients with PCOS have to be considered at risk of developing osteopenia when treated with GnRH-a. The relative protection against osteoporosis, that is present in amenorrheic patients with PCO, might be attributed to the characteristics of amenorrhea in these patients.
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页码：493 / 496
页数：3
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