Simultaneous Prediction of Retention Times and Peak Shapes of Sulfonamides in Reversed-Phase High-Performance Liquid Chromatography

被引：3

作者：

Wei X. ^{[1
,2
]}

Pang Z. ^{[1
]}

Fan G. ^{[1
]}

Xu X. ^{[1
]}

Wang L. ^{[3
]}

机构：

[1] School of Materials Science and Engineering, Tianjin University, Tianjin

[2] Department of Applied Chemical Engineering, Ningbo Polytechnic, Ningbo

[3] School of Agricultural and Food Engineering, Shandong University of Technology, Zibo

来源：

Transactions of Tianjin University | 2018年 / 24卷 / 03期

关键词：

Peak shape; Prediction; Retention time; RP-HPLC; Sulfonamide;

D O I：

10.1007/s12209-017-0110-x

中图分类号：

O62 [有机化学]; TQ [化学工业];

学科分类号：

070303 ; 0817 ; 081704 ;

摘要：

In this paper, we propose a novel method based on the plate theory to simultaneously predict retention times and peak shapes under gradient elutions and different flow rates by reversed-phase high-performance liquid chromatography. The proposed method yielded excellent retention prediction results in experiments with 16 common sulfonamides under 18 gradient conditions and four different flow rates, including 0.7, 1.0, 1.3, and 1.5 mL/min. The mean absolute deviation was 0.70%, which indicates accurate prediction. Moreover, the proposed method predicts the change well in peak shapes caused by the expansion or compression of peaks under different gradient conditions. © 2018, Tianjin University and Springer-Verlag GmbH Germany, part of Springer Nature.

引用

页码：256 / 262

页数：6

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