Immunosenescence in Caenorhabditis elegans

被引：0
作者：
Sieun S. Kim
Jooyeon Sohn
Seung-Jae V. Lee
机构：
[1] Korea Advanced Institute of Science and Technology,Department of Biological Sciences
来源：
Immunity & Ageing | / 19卷
关键词：
Immunosenescence; Aging; MAPK; SKN-1/NRF; Insulin/IGF-1;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescence is challenging because of the complexity of immune systems and aging in mammals. The roundworm Caenorhabditis elegans is suitable for understanding immunosenescence because of its simple immune system and rapid aging process. In this review, we discuss the advances in our understanding of immunosenescence in C. elegans. PMK-1/p38 mitogen-activated protein kinase (MAPK), SKN-1/NRF, and ZIP-10/bZIP transcription factor regulate immunosenescence through p38 MAPK and insulin/IGF-1 signaling pathways. Because these factors and pathways are evolutionarily conserved, the findings discussed in this review may help understand the mechanisms underlying immunosenescence and develop new treatment therapy for immunosenescence in humans.
引用
收藏
相关论文
共 50 条
[41]   Antioxidant and Antiaging Effects of Licorice on the Caenorhabditis elegans Model [J].
Reigada, Ines ;
Moliner, Cristina ;
Valero, Marta Sofia ;
Weinkove, David ;
Langa, Elisa ;
Gomez Rincon, Carlota .
JOURNAL OF MEDICINAL FOOD, 2020, 23 (01) :72-78
[42]   Quinacrine and rimonabant prolong the life span of Caenorhabditis elegans [J].
He, Qin ;
Guo, Shupan ;
Zhou, Aolan ;
Gong, Xin ;
Cheng, Wei ;
Ren, Haiyan .
GEROSCIENCE, 2025,
[43]   Global accumulation of circRNAs during aging in Caenorhabditis elegans [J].
Cortes-Lopez, Mariela ;
Gruner, Matthew R. ;
Cooper, Daphne A. ;
Gruner, Hannah N. ;
Voda, Alexandru-Ioan ;
van der Linden, Alexander M. ;
Miura, Pedro .
BMC GENOMICS, 2018, 19
[44]   Sex-specific regulation of aging in Caenorhabditis elegans [J].
Hotzi, Bernadette ;
Kosztelnik, Monika ;
Hargitai, Balazs ;
Takacs-Vellai, Krisztina ;
Barna, Janos ;
Borden, Kincso ;
Malnasi-Csizmadia, Andras ;
Lippai, Monika ;
Ortutay, Csaba ;
Bacquet, Caroline ;
Pasparaki, Angela ;
Aranyi, Tamas ;
Tavernarakis, Nektarios ;
Vellai, Tibor .
AGING CELL, 2018, 17 (03)
[45]   Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans [J].
Collins, James J. ;
Evason, Kimberley ;
Kornfeld, Kerry .
EXPERIMENTAL GERONTOLOGY, 2006, 41 (10) :1032-1039
[46]   Non-Coding RNAs in Caenorhabditis elegans Aging [J].
Kim, Sieun S. ;
Lee, Seung-Jae V. .
MOLECULES AND CELLS, 2019, 42 (05) :379-385
[47]   Global accumulation of circRNAs during aging in Caenorhabditis elegans [J].
Mariela Cortés-López ;
Matthew R. Gruner ;
Daphne A. Cooper ;
Hannah N. Gruner ;
Alexandru-Ioan Voda ;
Alexander M. van der Linden ;
Pedro Miura .
BMC Genomics, 19
[48]   Direct isolation of longevity mutants in the nematode Caenorhabditis elegans [J].
Duhon, SA ;
Murakami, S ;
Johnson, TE .
DEVELOPMENTAL GENETICS, 1996, 18 (02) :144-153
[49]   Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans [J].
Lashmanova, Ekaterina ;
Proshkina, Ekaterina ;
Zhikrivetskaya, Svetlana ;
Shevchenko, Oksana ;
Marusich, Elena ;
Leonov, Sergey ;
Melerzanov, Alex ;
Zhavoronkov, Alex ;
Moskalev, Alexey .
PHARMACOLOGICAL RESEARCH, 2015, 100 :228-241
[50]   Meiotic dysfunction accelerates somatic aging in Caenorhabditis elegans [J].
Loose, Julia A. ;
Amrit, Francis R. G. ;
Patil, Thayjas ;
Yanowitz, Judith L. ;
Ghazi, Arjumand .
AGING CELL, 2022, 21 (11)
12345