Immunosenescence in Caenorhabditis elegans

被引：0
作者：
Sieun S. Kim
Jooyeon Sohn
Seung-Jae V. Lee
机构：
[1] Korea Advanced Institute of Science and Technology,Department of Biological Sciences
来源：
Immunity & Ageing | / 19卷
关键词：
Immunosenescence; Aging; MAPK; SKN-1/NRF; Insulin/IGF-1;
D O I：
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学科分类号：
摘要：
Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescence is challenging because of the complexity of immune systems and aging in mammals. The roundworm Caenorhabditis elegans is suitable for understanding immunosenescence because of its simple immune system and rapid aging process. In this review, we discuss the advances in our understanding of immunosenescence in C. elegans. PMK-1/p38 mitogen-activated protein kinase (MAPK), SKN-1/NRF, and ZIP-10/bZIP transcription factor regulate immunosenescence through p38 MAPK and insulin/IGF-1 signaling pathways. Because these factors and pathways are evolutionarily conserved, the findings discussed in this review may help understand the mechanisms underlying immunosenescence and develop new treatment therapy for immunosenescence in humans.
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