Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers

被引：0
作者：
Stefan Jehle
Ponni Rajagopal
Benjamin Bardiaux
Stefan Markovic
Ronald Kühne
Joseph R Stout
Victoria A Higman
Rachel E Klevit
Barth-Jan van Rossum
Hartmut Oschkinat
机构：
[1] Leibniz-Institut Für Molekulare Pharmakologie,Department of Biochemistry
[2] Freie Universität Berlin,undefined
[3] University of Washington,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
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摘要：
The structure of the small heat shock protein αB-crystallin, associated with multiple sclerosis and Alzheimer's disease, has eluded biologists for years. Small angle X-ray scattering and solid-state NMR reveal a curved dimer that modulates substrate interactions upon a change in pH.
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页码：1037 / 1042
页数：5
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共 101 条
[1]  
Bukau B(2006)Molecular chaperones and protein quality control Cell 125 443-451
[2]  
Weissman J(2005)Some like it hot: the structure and function of small heat-shock proteins Nat. Struct. Mol. Biol. 12 842-846
[3]  
Horwich A(2009)Crystallin proteins and amyloid fibrils Cell. Mol. Life Sci. 66 62-81
[4]  
Haslbeck M(1992)α-crystallin can function as a molecular chaperone Proc. Natl. Acad. Sci. USA 89 10449-10453
[5]  
Franzmann T(2006)Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-αB crystallin) complex Mol. Cell 24 355-366
[6]  
Weinfurtner D(2003)Cytosolic β-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease Lancet 361 1258-1265
[7]  
Buchner J(2001)Ser-59 is the major phosphorylation site in αB-crystallin accumulated in the brains of patients with Alexander's disease J. Neurochem. 76 730-736
[8]  
Ecroyd H(1998)A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy Nat. Genet. 20 92-95
[9]  
Carver JA(2007)Human α B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice Cell 130 427-439
[10]  
Horwitz J(2006)A novel αB-crystallin mutation associated with autosomal dominant congenital lamellar cataract Invest. Ophthalmol. Vis. Sci. 47 1069-1075
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