Stem Cell-Based Therapeutic Applications in Retinal Degenerative Diseases

被引：0
作者：
Yiming Huang
Volker Enzmann
Suzanne T. Ildstad
机构：
[1] University of Louisville,Institute for Cellular Therapeutics
[2] University of Bern,Department of Ophthalmology, Inselspital
来源：
Stem Cell Reviews and Reports | 2011年 / 7卷
关键词：
Retinal degeneration; Stem cells; Regeneration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy, cataracts, and glaucoma. Effective treatment for retinal degeneration has been widely investigated. Gene-replacement therapy has been shown to improve visual function in inherited retinal disease. However, this treatment was less effective with advanced disease. Stem cell-based therapy is being pursued as a potential alternative approach in the treatment of retinal degenerative diseases. In this review, we will focus on stem cell-based therapies in the pipeline and summarize progress in treatment of retinal degenerative disease.
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页码：434 / 445
页数：11
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