Genome-wide association study identifies 48 common genetic variants associated with handedness

被引：0

作者：

Gabriel Cuellar-Partida

Joyce Y. Tung

Nicholas Eriksson

Eva Albrecht

Fazil Aliev

Ole A. Andreassen

Inês Barroso

Jacques S. Beckmann

Marco P. Boks

Dorret I. Boomsma

Heather A. Boyd

Monique M. B. Breteler

Harry Campbell

Daniel I. Chasman

Lynn F. Cherkas

Gail Davies

Eco J. C. de Geus

Ian J. Deary

Panos Deloukas

Danielle M. Dick

David L. Duffy

Johan G. Eriksson

Tõnu Esko

Bjarke Feenstra

Frank Geller

Christian Gieger

Ina Giegling

Scott D. Gordon

Jiali Han

Thomas F. Hansen

Annette M. Hartmann

Caroline Hayward

Kauko Heikkilä

Andrew A. Hicks

Joel N. Hirschhorn

Jouke-Jan Hottenga

Jennifer E. Huffman

Liang-Dar Hwang

M. Arfan Ikram

Jaakko Kaprio

John P. Kemp

Kay-Tee Khaw

Norman Klopp

Bettina Konte

Zoltan Kutalik

Jari Lahti

Xin Li

Ruth J. F. Loos

Michelle Luciano

Sigurdur H. Magnusson

机构：

[1] The University of Queensland,The University of Queensland Diamantina Institute

[2] 23andMe,Institute of Genetic Epidemiology

[3] Inc.,Department of Psychology

[4] Helmholtz Zentrum München—German Research Center for Environmental Health,NORMENT, Institute of Clinical Medicine

[5] Virginia Commonwealth University,Division of Mental Health and Addiction

[6] Karabuk University,Human Genetics

[7] Faculty of Business,MRC Epidemiology Unit

[8] University of Oslo,Wellcome–MRC Institute of Metabolic Science

[9] Oslo University Hospital,Service of Medical Genetics

[10] Wellcome Sanger Institute,Department of Psychiatry, UMC Utrecht Brain Center

[11] University of Cambridge,Department of Biological Psychology

[12] University of Cambridge,Amsterdam Public Health research institute

[13] Centre Hospitalier Universitaire Vaudois and University of Lausanne,Department of Epidemiology Research

[14] University Utrecht,Population Health Sciences

[15] Vrije Universiteit,Usher Institute of Population Health Sciences and Informatics

[16] Amsterdam University Medical Centers,Division of Preventive Medicine

[17] Statens Serum Institut,Department of Twin Research and Genetic Epidemiology

[18] German Center for Neurodegenerative Diseases (DZNE),Department of Psychology

[19] University of Edinburgh,Centre for Cognitive Ageing and Cognitive Epidemiology

[20] Brigham and Women’s Hospital,William Harvey Research Institute, Barts and the London Medical School, and the Centre for Genomic Health

[21] Harvard Medical School,Department of Human and Molecular Genetics

[22] King’s College London,Genetic Epidemiology

[23] University of Edinburgh,Department of General Practice and Primary Health Care

[24] University of Edinburgh,Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine

[25] Queen Mary University of London,Estonian Genome Centre, Institute of Genomics

[26] Virginia Commonwealth University,Program in Medical and Population Genetics

[27] QIMR Berghofer Medical Research Institute,Research Unit of Molecular Epidemiology

[28] University of Helsinki and Helsinki University Hospital,German Center for Diabetes Research (DZD)

[29] Folkhälsan Research Center,University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics

[30] Singapore Institute for Clinical Sciences,Department of Epidemiology, Richard M. Fairbanks School of Public Health

[31] Agency for Science Technology and Research,Melvin and Bren Simon Cancer Center

[32] National University of Singapore,Institute of Biological Psychiatry

[33] University of Tartu,Danish Headache Center

[34] Broad Institute of MIT and Harvard,MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine

[35] Institute of Epidemiology,Institute for Molecular Medicine FIMM

[36] Helmholtz Zentrum München—German Research Center for Environmental Health,Institute for Biomedicine

[37] München–Neuherberg,Division of Endocrinology

[38] Martin-Luther-University Halle-Wittenberg,Department of Genetics

[39] Indiana University,Medical and Population Genetics

[40] Indiana University,Department of Epidemiology, Erasmus MC

[41] Mental Health Services of Copenhagen,Department of Public Health

[42] Copenhagen University Hospital,Medical Research Council Integrative Epidemiology Unit

[43] University of Edinburgh,Public Health and Primary Care

[44] University of Helsinki,Hannover Unified Biobank

[45] Eurac Research,Center for Primary Care and Public Health

[46] Boston Children’s Hospital,Department of Psychology and Logopedics

[47] Harvard Medical School,Turku Institute for Advanced Studies

[48] Broad Institute,Department of Psychology and Logopedics, Faculty of Medicine

[49] University Medical Center,The Charles Bronfman Institute for Personalized Medicine

[50] University of Helsinki,The Mindich Child Health and Development Institute

来源：

Nature Human Behaviour | 2021年 / 5卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10−8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.

引用

页码：59 / 70

页数：11

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