Is there a link between the neutrophil-to-lymphocyte ratio and venous thromboembolic events after knee arthroplasty? A pilot study

被引：38

作者：

Barker T. ^{[1
]}

Rogers V.E. ^{[1
]}

Henriksen V.T. ^{[1
]}

Brown K.B. ^{[1
]}

Trawick R.H. ^{[2
]}

Momberger N.G. ^{[2
]}

Lynn Rasmussen G. ^{[2
]}

机构：

[1] The Orthopedic Specialty Hospital, 5848 S. Fashion Blvd., Murray, 84107, UT

[2] The Orthopedic Specialty Clinic, 5848 S. Fashion Blvd, Murray, 84107, UT

来源：

Journal of Orthopaedics and Traumatology | 2016年 / 17卷 / 2期

关键词：

Lymphocyte; Neutrophil; Total knee arthroplasty; Unicompartmental knee arthroplasty; Venous thromboembolic event;

D O I：

10.1007/s10195-015-0378-3

中图分类号：

学科分类号：

摘要：

Background: This study aimed to identify (1) if the postoperative increase in the neutrophil-to-lymphocyte ratio (NLR) is different between contrasting knee arthroplasty procedures, and (2) if the NLR predicts venous thromboembolism (VTE) after total knee arthroplasty (TKA). Materials and methods: To address the first objective, we retrospectively studied patients who underwent primary unilateral TKA (n = 111) or unicompartmental knee arthroplasty (UKA; n = 74) between 2009 and 2012. Patients who required a blood transfusion, underwent autologous blood salvage, experienced any postoperative complication (such as VTE), or were re-admitted >90 days were excluded from analysis. For the second objective, we retrospectively identified patients (cases, n = 10) who underwent primary unilateral TKA between 2010 and 2012 and developed postoperative VTE (deep venous thrombosis, pulmonary embolism, or both) during inpatient care (postoperative day 1 or day 2). Cases were matched to surgeon, gender, body mass index, age, and date of surgery controls (n = 20) who underwent primary unilateral TKA without developing VTE before patient discharge. The NLR was calculated from the neutrophil and lymphocyte counts extracted from pre- and postoperative (day 1 and day 2) blood chemistry records. Results: On postoperative day 1, the NLR increase was exacerbated (p = 0.02) following TKA compared to UKA and predicted (p = 0.02) the occurrence of VTE in TKA patients prior to hospital discharge. Conclusion: We conclude that the NLR increase is greater following TKA compared to UKA and could serve as a matrix to predict or identify a patient susceptible of sustaining VTE after TKA. Level of evidence: 3. © 2015, The Author(s).

引用

页码：163 / 168

页数：5

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