Tumorigenesis: Twist1 links EMT to self-renewal

被引：0
|
作者：
Alberto Martin
Amparo Cano
机构：
[1] Facultad de Medicina,Alberto Martin and Amparo Cano are in the Departamento de Bioquímica
[2] Universidad Autónoma de Madrid,undefined
[3] IdiPAZ,undefined
[4] Arzobispo Morcillo,undefined
[5] 2,undefined
[6] 28029 Madrid,undefined
[7] Spain and the Instituto de Investigaciones Biomédicas “Alberto Sols” Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid,undefined
[8] Arzobispo Morcillo,undefined
[9] 2,undefined
[10] 28029 Madrid,undefined
[11] Spain.,undefined
来源：
Nature Cell Biology | 2010年 / 12卷
关键词：
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学科分类号：
摘要：
The epithelial–mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.
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页码：924 / 925
页数：1
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