Ribosome-dependent activation of stringent control

被引：0
|
作者：
Alan Brown
Israel S. Fernández
Yuliya Gordiyenko
V. Ramakrishnan
机构：
[1] MRC Laboratory of Molecular Biology,
[2] †Present address: Department of Biochemistry and Molecular Biophysics,undefined
[3] Columbia University,undefined
[4] New York,undefined
[5] New York 10032,undefined
[6] USA.,undefined
来源：
Nature | 2016年 / 534卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The structure of a bacterial ribosome–RelA complex reveals that RelA, a protein recruited to the ribosome in the case of scarce amino acids, binds in a different location to translation factors, and that this binding event suppresses auto-inhibition to activate synthesis of the (p)ppGpp secondary messenger, thus initiating stringent control.
引用
收藏
页码：277 / 280
页数：3
相关论文
共 50 条
  • [41] STRINGENT CONTROL AND GROWTH-RATE-DEPENDENT CONTROL HAVE NONIDENTICAL PROMOTER SEQUENCE REQUIREMENTS
    JOSAITIS, CA
    GAAL, T
    GOURSE, RL
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) : 1117 - 1121
  • [42] The ribosome triggers the stringent response by RelA via a highly distorted tRNA
    Agirrezabala, Xabier
    Fernandez, Israel S.
    Kelley, Ann C.
    Gil Carton, David
    Ramakrishnan, Venki
    Valle, Mikel
    EMBO REPORTS, 2013, 14 (09) : 811 - 816
  • [43] Ribosomal protein L7/L12 is required for ribosome-dependent GTPase binding and activity for GTPase translation factors harboring a G' domain
    Weis, Amanda
    Haddad, Bassam
    Blackwood, Colby
    Shelton, Catherine
    Carlson, Markus
    Spiegel, P. Clint
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 252
  • [44] AMBER SUPPRESSION RELAXES STRINGENT CONTROL BY ELONGATING STRINGENT FACTOR
    BREEDEN, L
    YARUS, M
    MOLECULAR AND GENERAL GENETICS, 1982, 187 (02): : 254 - 264
  • [45] STRINGENT CONTROL OF BACTERIAL TRANSCRIPTION
    LAMOND, AI
    TRAVERS, AA
    CELL, 1985, 41 (01) : 6 - 8
  • [46] POLYAMINES AND STRINGENT CONTROL OF TRANSCRIPTION
    GOLDEMBERG, SH
    UTTARO, A
    ANALES DE LA ASOCIACION QUIMICA ARGENTINA, 1989, 77 (01): : 41 - 46
  • [47] Argonaute-dependent ribosome-associated protein quality control
    Gao, Yajie
    Zhu, Yuanxiang
    Sun, Qinmiao
    Chen, Dahua
    TRENDS IN CELL BIOLOGY, 2023, 33 (03) : 260 - 272
  • [48] Control of ribosome traffic by position-dependent choice of synonymous codons
    Mitarai, Namiko
    Pedersen, Steen
    PHYSICAL BIOLOGY, 2013, 10 (05)
  • [49] The Stringent Response Inhibits 70S Ribosome Formation in Staphylococcus aureus by Impeding GTPase-Ribosome Interactions
    Bennison, Daniel J.
    Nakamoto, Jose A.
    Craggs, Timothy D.
    Milon, Pohl
    Rafferty, John B.
    Corrigan, Rebecca M.
    MBIO, 2021, 12 (06):
  • [50] BASIS OF STRINGENT/RELAXED CONTROL
    不详
    NATURE, 1972, 237 (5352) : 199 - &
12345