Risk of Upper Gastrointestinal Bleeding and the Degree of Serotonin Reuptake Inhibition by AntidepressantsA Case-Control Study

被引：0

作者：

Xavier Vidal

Luisa Ibáñez

Lourdes Vendrell

Ana Conforti

Joan-Ramon Laporte

机构：

[1] Universitat Autònoma de Barcelona,Department of Pharmacology, Therapeutics and Toxicology

[2] WHO Collaborating Centre for Research and Training in Pharmacoepidemiology,Foundation Catalan Institute of Pharmacology

[3] Hospital Universitari Vall d’Hebron,Clinical Pharmacology Service

[4] University of Verona,Clinical Pharmacology Unit, Department of Medicine and Public Health, Policlinico ‘GB Rossi’

来源：

Drug Safety | 2008年 / 31卷

关键词：

Gastrointestinal Bleeding; Selective Serotonin Reuptake Inhibitor; Fluvoxamine; Mirtazapine; Serotonin Transporter;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Background and objective: Selective serotonin reuptake inhibitor (SSRI) antidepressants can inhibit uptake of serotonin by platelets, and their use may predispose patients to bleeding. Case reports and observational studies from databases have suggested an association between the use of SSRIs and gastrointestinal bleeding. Their risk appears to be increased if they are concurrently used with aspirin (acetylsalicylic acid) or with other NSAIDs. With the aim of establishing the risk of major upper gastrointestinal bleeding associated with various groups of drugs, we performed a multicentre case-control study. We present the results related to the use of antidepressants by the degree of serotonin reuptake inhibition they induce, the selectivity at monoamine transporters and the dose.

引用

页码：159 / 168

页数：9