Synthesis and immunomodulating properties of poly(N-vinylformamide)

被引：0

作者：

E. F. Panarin

N. A. Nesterova

I. I. Gavrilova

N. P. Ivanova

A. T. Belokhvostova

L. S. Potapenkova

机构：

[1] Russian Academy of Sciences,Institute of Macromolecular Compounds

[2] Ministry of Public Health of the Russian Federation,Petrov Institute of Oncology

来源：

Pharmaceutical Chemistry Journal | 2011年 / 44卷

关键词：

poly(; -vinylformamide); immunostimulating activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of poly(N-vinylformamide) (PNVF) samples with molecular masses in the range (8.7 – 280) × 103 were synthesized. The effect of the polymer molecular mass on the PNVF-stimulated antibody response was investigated using BALB/C mice (Rappolovo nursery). The immunostimulating activity of the polymer was estimated by its influence on the appearance of antibody-forming cells to sheep red blood cells by the local hemolysis method in gel. A strong dependence of the antibody response on the polymer molecular mass was observed. The maximum activity was manifested for PNVF with molecular masses in the range (55 – 85) × 103.

引用

页码：528 / 529

页数：1