Functional interactions of Na,K-ATPase with molecular environment

被引：1
作者：
Krivoi I.I. [1 ]
机构：
[1] St. Petersburg State University, St. Petersburg
来源：
Biophysics | 2014年 / 59卷 / 5期
关键词：
cardiotonic steroids; isoforms; lipid microdomains; Na; K-ATPase; signal and neuroprotective function; synaptic transmission;
D O I：
10.1134/S000635091405011X
中图分类号：
学科分类号：
摘要：
The present review covers the analysis of research in the field of intermolecular interactions of Na,K-ATPase which underlie novel cellular regulatory mechanisms. The capability of Na,K-ATPase to form multimolecular regulatory complexes and take part as a scaffolding protein in formation of cell functional and signaling microcompartments is considered. Particular attention is directed to membrane lipid microdomains (rafts, caveolae). Mechanisms of signaling and neuroprotective functions of Na,K-ATPase as well as the involvement of endogenous cardiotonic steroids in their realization are discussed. This review demonstrates novel data on functional interactions of Na,K-ATPase with neurotransmitter receptors and other proteins involved in regulation of synaptic transmission. © 2014, Pleiades Publishing, Inc.
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页码：708 / 717
页数：9
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