Functional interactions of Na,K-ATPase with molecular environment

被引：1
|
作者：
Krivoi I.I. [1 ]
机构：
[1] St. Petersburg State University, St. Petersburg
来源：
Biophysics | 2014年 / 59卷 / 5期
关键词：
cardiotonic steroids; isoforms; lipid microdomains; Na; K-ATPase; signal and neuroprotective function; synaptic transmission;
D O I：
10.1134/S000635091405011X
中图分类号：
学科分类号：
摘要：
The present review covers the analysis of research in the field of intermolecular interactions of Na,K-ATPase which underlie novel cellular regulatory mechanisms. The capability of Na,K-ATPase to form multimolecular regulatory complexes and take part as a scaffolding protein in formation of cell functional and signaling microcompartments is considered. Particular attention is directed to membrane lipid microdomains (rafts, caveolae). Mechanisms of signaling and neuroprotective functions of Na,K-ATPase as well as the involvement of endogenous cardiotonic steroids in their realization are discussed. This review demonstrates novel data on functional interactions of Na,K-ATPase with neurotransmitter receptors and other proteins involved in regulation of synaptic transmission. © 2014, Pleiades Publishing, Inc.
引用
收藏
页码：708 / 717
页数：9
相关论文
共 50 条
  • [1] FUNCTIONAL AND MOLECULAR INTERACTIONS BETWEEN AQUAPORINS AND Na,K-ATPase
    Illarionova, N. B.
    Gunnarson, E.
    Li, Y.
    Brismar, H.
    Bondar, A.
    Zelenin, S.
    Aperia, A.
    NEUROSCIENCE, 2010, 168 (04) : 915 - 925
  • [2] Specialized Functional Diversity and Interactions of the Na,K-ATPase
    Matchkov, Vladimir V.
    Krivoi, Igor I.
    FRONTIERS IN PHYSIOLOGY, 2016, 7
  • [3] Structure and mechanism of Na,K-ATPase:: Functional sites and their interactions
    Jorgensen, PL
    Håkansson, KO
    Karlish, SJD
    ANNUAL REVIEW OF PHYSIOLOGY, 2003, 65 : 817 - 849
  • [4] Molecular and Functional Heterogeneity of Na,K-ATPase in the Skeletal Muscle
    Kravtsova, V. V.
    Krivoi, I. I.
    JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2021, 57 (04) : 835 - 851
  • [5] Molecular and Functional Heterogeneity of Na,K-ATPase in the Skeletal Muscle
    V. V. Kravtsova
    I. I. Krivoi
    Journal of Evolutionary Biochemistry and Physiology, 2021, 57 : 835 - 851
  • [6] THE NA,K-ATPASE MOLECULAR MECHANISM
    KOMETIANI, ZP
    JOURNAL OF GENERAL PHYSIOLOGY, 1990, 96 (06): : A49 - A49
  • [7] FUNCTIONAL-PROPERTIES OF AN H,K-ATPASE/NA,K-ATPASE CHIMERA
    BLOSTEIN, R
    ZHANG, RP
    GOTTARDI, CJ
    CAPLAN, MJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1993, 268 (14) : 10654 - 10658
  • [8] Stabilization of Na,K-ATPase by ionic interactions
    Fodor, Elfrieda
    Fedosova, Natalya U.
    Ferencz, Csilla
    Marsh, Derek
    Pali, Tibor
    Esmann, Mikael
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2008, 1778 (04): : 835 - 843
  • [9] Na,K-ATPase in the myocardium:: Molecular principles, functional and clinical aspects
    Ziegelhöffer, A
    Kjeldsen, K
    Bundgaard, H
    Breier, A
    Vrbjar, N
    Dzurba, A
    GENERAL PHYSIOLOGY AND BIOPHYSICS, 2000, 19 (01) : 9 - 47
  • [10] Quantification and functional studies of a NA,K-ATPase and H,K-ATPase chimera.
    Bray, A
    Ferraris, E
    McGill, DL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U490 - U490
12345